Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients

Katalin Réka Kovács, Csilla Cecília Szekeres, Zoltán Bajkó, Krisztina Csapó, Sándor Molnár, László Oláh, Mária Tünde Magyar, Dániel Bereczki, László Kardos, Pál Soltész, Andrea Burainé Bojtor, László Csiba

Research output: Contribution to journalArticle

10 Citations (Scopus)


Background: Hypertensive (HT) patients are at higher risk of cognitive decline than normotensive individuals, because high blood pressure is a risk factor for mild cognitive deterioration. In this study cardio- and cerebrovascular reactivity along with cognitive performance was assessed on newly diagnosed HT patients. Methods: Diagnosis of hypertension was based on international recommendations. None of the patients had diabetes, and all of them had normal cerebral CT scan. Eighty-one patients (43.5 ± 10.2 years, male/female ratio: 42/39) were compared with 94 healthy controls (44 ± 9.4 years, male/female ratio: 50/44). In both groups continuous, non-invasive and simultaneous monitoring of cerebral and cardiac hemodynamical parameters were recorded during head-up tilt table testing (HUTT). Reaction time, attention and memory skills, anxiety and depression rate were determined by neuropsychological tests. Results: During HUTT significant differences were found in certain cardiovascular parameters (blood pressure, total peripheral resistance index, stroke index), but no differences were detected in cerebral blood flow velocity. While there was no significant difference in reaction time between the two groups, tests estimating short-term memory (Digit Span Test) differed significantly. Moreover, sum of standardized test scores was significantly lower, while anxiety level was significantly increased in HT patients compared to controls. Conclusion: Decrease in neuropsychological performance along with alterations of cardiovascular parameters is an early manifestation of hypertension. Aim for an early intervention and accurate treatment is crucial for preventing further impairments.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Dec 15 2010


  • Anxiety
  • Cognitive performance
  • Head-up tilt table test
  • Hypertension
  • Neuropsychological tests

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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