Cerebral metastases pathology after radiosurgery

A multicenter study

G. Szeifert, Dave S. Atteberry, Douglas Kondziolka, Marc Levivier, L. Dade Lunsford

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

BACKGROUND. To the authors' knowledge, comprehensive human pathologic investigations that explore fundamental radiosurgical effects on metastatic brain tumors are sparse in the literature. The objective of this study was to analyze histopathologic findings in a set of clinically recurrent cerebral metastases after patients underwent stereotactic radiosurgery (SRS). METHODS. In a series of 7500 patients who underwent radiosurgery, 2020 patients (27%) harbored cerebral metastases. Eighteen of 2020 patients (0.9%) underwent subsequent craniotomy for tumor removal anywhere from 1 month to 59 months after they received high-dose irradiation. Histologic and immunohistochemical investigations were performed on the surgically resected tissue specimens. These specimens were within the radiosurgical treatment volume of the metastatic tumor. RESULTS. Light microscopy revealed 3 basic categories of histologic responses: acute-type, subacute-type, and chronic-type tissue reactions. A moderate-to-intense inflammatory cell reaction was seen in the tissue responses of well controlled neoplasms (i.e., in patients who had neoplasms that required craniotomy for recurrent disease >5 months after SRS), whereas the inflammatory reaction was missing or sparse in poorly controlled neoplasms (patients who required craniotomy for recurrent disease

Original languageEnglish
Pages (from-to)2672-2681
Number of pages10
JournalCancer
Volume106
Issue number12
DOIs
Publication statusPublished - Jun 15 2006

Fingerprint

Radiosurgery
Multicenter Studies
Pathology
Neoplasm Metastasis
Craniotomy
Neoplasms
Tumor Burden
Brain Neoplasms
Microscopy
Light

Keywords

  • Cellular immunity
  • Cerebral metastases
  • Gamma knife radiosurgery
  • Inflammatory reaction
  • Radiosurgical pathology
  • T lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Szeifert, G., Atteberry, D. S., Kondziolka, D., Levivier, M., & Lunsford, L. D. (2006). Cerebral metastases pathology after radiosurgery: A multicenter study. Cancer, 106(12), 2672-2681. https://doi.org/10.1002/cncr.21946

Cerebral metastases pathology after radiosurgery : A multicenter study. / Szeifert, G.; Atteberry, Dave S.; Kondziolka, Douglas; Levivier, Marc; Lunsford, L. Dade.

In: Cancer, Vol. 106, No. 12, 15.06.2006, p. 2672-2681.

Research output: Contribution to journalArticle

Szeifert, G, Atteberry, DS, Kondziolka, D, Levivier, M & Lunsford, LD 2006, 'Cerebral metastases pathology after radiosurgery: A multicenter study', Cancer, vol. 106, no. 12, pp. 2672-2681. https://doi.org/10.1002/cncr.21946
Szeifert G, Atteberry DS, Kondziolka D, Levivier M, Lunsford LD. Cerebral metastases pathology after radiosurgery: A multicenter study. Cancer. 2006 Jun 15;106(12):2672-2681. https://doi.org/10.1002/cncr.21946
Szeifert, G. ; Atteberry, Dave S. ; Kondziolka, Douglas ; Levivier, Marc ; Lunsford, L. Dade. / Cerebral metastases pathology after radiosurgery : A multicenter study. In: Cancer. 2006 ; Vol. 106, No. 12. pp. 2672-2681.
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