Cercopithecus aethiops monkey as a reliable model for in vitro study of T cell depletion of bone marrow with Campath-1 plus complement.

D. T. Phan, M. Benczur, J. Gidáli, I. Fehér, V. Harsányi, L. Nemes, G. Petrányi, S. Hollán

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

T-lymphocyte markers of peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of C. aethiops monkeys were studied by using anti-human monoclonal antibodies. The results show that C. aethiops T lymphocytes express surface markers which react specifically with anti-human MoAbs including CD3, CD4, CD8, CD2. However, very few CD3-positive cells were found, in contrast to the abundance in CD8+ cells. There is a high conservation of receptors forming E rosettes with AET-treated SRBCs, and antigens reacting with the anti-human T and B cell monoclonal antibody (Campath-1). The present findings indicate that C. aethiops can be used as a new experimental model for studies on T-cell depletion from bone marrow with Campath-1 MoAb + rabbit C.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalFolia haematologica : internationales Magazin fur klinische und morphologische Blutforschung
Volume116
Issue number1
Publication statusPublished - 1989

Fingerprint

Complement C1
Cercopithecus aethiops
Haplorhini
Bone Marrow
T-Lymphocytes
beta-Aminoethyl Isothiourea
Monoclonal Antibodies
Bone Marrow Cells
Blood Cells
B-Lymphocytes
Theoretical Models
Rabbits
Antigens
alemtuzumab
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{6b976b7a2637481387184336bc4d7207,
title = "Cercopithecus aethiops monkey as a reliable model for in vitro study of T cell depletion of bone marrow with Campath-1 plus complement.",
abstract = "T-lymphocyte markers of peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of C. aethiops monkeys were studied by using anti-human monoclonal antibodies. The results show that C. aethiops T lymphocytes express surface markers which react specifically with anti-human MoAbs including CD3, CD4, CD8, CD2. However, very few CD3-positive cells were found, in contrast to the abundance in CD8+ cells. There is a high conservation of receptors forming E rosettes with AET-treated SRBCs, and antigens reacting with the anti-human T and B cell monoclonal antibody (Campath-1). The present findings indicate that C. aethiops can be used as a new experimental model for studies on T-cell depletion from bone marrow with Campath-1 MoAb + rabbit C.",
author = "Phan, {D. T.} and M. Benczur and J. Gid{\'a}li and I. Feh{\'e}r and V. Hars{\'a}nyi and L. Nemes and G. Petr{\'a}nyi and S. Holl{\'a}n",
year = "1989",
language = "English",
volume = "116",
pages = "97--106",
journal = "Folia haematologica; internationales Magazin fur Blutforschung",
issn = "0015-556X",
publisher = "Akademische Verlagsgesellschaft",
number = "1",

}

TY - JOUR

T1 - Cercopithecus aethiops monkey as a reliable model for in vitro study of T cell depletion of bone marrow with Campath-1 plus complement.

AU - Phan, D. T.

AU - Benczur, M.

AU - Gidáli, J.

AU - Fehér, I.

AU - Harsányi, V.

AU - Nemes, L.

AU - Petrányi, G.

AU - Hollán, S.

PY - 1989

Y1 - 1989

N2 - T-lymphocyte markers of peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of C. aethiops monkeys were studied by using anti-human monoclonal antibodies. The results show that C. aethiops T lymphocytes express surface markers which react specifically with anti-human MoAbs including CD3, CD4, CD8, CD2. However, very few CD3-positive cells were found, in contrast to the abundance in CD8+ cells. There is a high conservation of receptors forming E rosettes with AET-treated SRBCs, and antigens reacting with the anti-human T and B cell monoclonal antibody (Campath-1). The present findings indicate that C. aethiops can be used as a new experimental model for studies on T-cell depletion from bone marrow with Campath-1 MoAb + rabbit C.

AB - T-lymphocyte markers of peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of C. aethiops monkeys were studied by using anti-human monoclonal antibodies. The results show that C. aethiops T lymphocytes express surface markers which react specifically with anti-human MoAbs including CD3, CD4, CD8, CD2. However, very few CD3-positive cells were found, in contrast to the abundance in CD8+ cells. There is a high conservation of receptors forming E rosettes with AET-treated SRBCs, and antigens reacting with the anti-human T and B cell monoclonal antibody (Campath-1). The present findings indicate that C. aethiops can be used as a new experimental model for studies on T-cell depletion from bone marrow with Campath-1 MoAb + rabbit C.

UR - http://www.scopus.com/inward/record.url?scp=0024491459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024491459&partnerID=8YFLogxK

M3 - Article

C2 - 2472335

AN - SCOPUS:0024491459

VL - 116

SP - 97

EP - 106

JO - Folia haematologica; internationales Magazin fur Blutforschung

JF - Folia haematologica; internationales Magazin fur Blutforschung

SN - 0015-556X

IS - 1

ER -