Ceramide modulation of antigen-triggered Ca2+ signals and cell fate: Diversity in the responses of various immunocytes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Ceramide is a widely accepted mediator of T cell apoptosis and is released upon receiving various death or stress signals. Recently we have shown that the fate of T cells, life or death, depends strictly on the strength and duration of the ceramide-generating stimulus. Subapoptotic ceramide signals were shown to negatively regulate the antigen-specific activation signaling in T cells. Here we show that these subapoptotic ceramide signals also inhibit the antigen-triggered Ca2+ signals in B lymphocytes or the FcεRI-mediated response of mast cells to antigen, but in a differential manner. Burkitt B lymphoma cells, frequently used models of mature B cells, and marginal zone B cells were largely resistant to the inhibitory action of ceramide. The response to cell death-inducing (strong/long duration) ceramide stimuli, resulting in massive apoptosis in T cells, was also differential among the various immunocytes in terms of both the death mechanism and the sensitivity. Our data suggest that ceramide's effects on life and death signaling in immunocytes are cell type-/stage-specific.

Original languageEnglish
Title of host publicationSignal Transduction Pathways, Part A
Subtitle of host publicationApoptotic and Extracellular Signalling
PublisherBlackwell Publishing Inc.
Pages161-167
Number of pages7
ISBN (Print)1573316458, 9781573316453
DOIs
Publication statusPublished - Dec 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1090
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Antigen-triggered immunocyte activation
  • Ca signals
  • Ceramides
  • Rafts
  • Sphingolipids
  • Stress and death signals

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Kiss, E., Śarmay, G., & Matkó, J. (2006). Ceramide modulation of antigen-triggered Ca2+ signals and cell fate: Diversity in the responses of various immunocytes. In Signal Transduction Pathways, Part A: Apoptotic and Extracellular Signalling (pp. 161-167). (Annals of the New York Academy of Sciences; Vol. 1090). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1378.017