Ceramide modulation of antigen-triggered Ca2+ signals and cell fate: Diversity in the responses of various immunocytes

Endre Kiss, G. Sármay, J. Matkó

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Ceramide is a widely accepted mediator of T cell apoptosis and is released upon receiving various death or stress signals. Recently we have shown that the fate of T cells, life or death, depends strictly on the strength and duration of the ceramide-generating stimulus. Subapoptotic ceramide signals were shown to negatively regulate the antigen-specific activation signaling in T cells. Here we show that these subapoptotic ceramide signals also inhibit the antigen-triggered Ca2+ signals in B lymphocytes or the FcεRI-mediated response of mast cells to antigen, but in a differential manner. Burkitt B lymphoma cells, frequently used models of mature B cells, and marginal zone B cells were largely resistant to the inhibitory action of ceramide. The response to cell death-inducing (strong/long duration) ceramide stimuli, resulting in massive apoptosis in T cells, was also differential among the various immunocytes in terms of both the death mechanism and the sensitivity. Our data suggest that ceramide's effects on life and death signaling in immunocytes are cell type-/stage-specific.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages161-167
Number of pages7
Volume1090
DOIs
Publication statusPublished - Dec 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1090
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Ceramides
Modulation
T-cells
Antigens
T-Lymphocytes
B-Lymphocytes
Cells
Apoptosis
Burkitt Lymphoma
Lymphocytes
Cell death
Mast Cells
Cell Death
Chemical activation

Keywords

  • Antigen-triggered immunocyte activation
  • Ca signals
  • Ceramides
  • Rafts
  • Sphingolipids
  • Stress and death signals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kiss, E., Sármay, G., & Matkó, J. (2006). Ceramide modulation of antigen-triggered Ca2+ signals and cell fate: Diversity in the responses of various immunocytes. In Annals of the New York Academy of Sciences (Vol. 1090, pp. 161-167). (Annals of the New York Academy of Sciences; Vol. 1090). https://doi.org/10.1196/annals.1378.017

Ceramide modulation of antigen-triggered Ca2+ signals and cell fate : Diversity in the responses of various immunocytes. / Kiss, Endre; Sármay, G.; Matkó, J.

Annals of the New York Academy of Sciences. Vol. 1090 2006. p. 161-167 (Annals of the New York Academy of Sciences; Vol. 1090).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kiss, E, Sármay, G & Matkó, J 2006, Ceramide modulation of antigen-triggered Ca2+ signals and cell fate: Diversity in the responses of various immunocytes. in Annals of the New York Academy of Sciences. vol. 1090, Annals of the New York Academy of Sciences, vol. 1090, pp. 161-167. https://doi.org/10.1196/annals.1378.017
Kiss E, Sármay G, Matkó J. Ceramide modulation of antigen-triggered Ca2+ signals and cell fate: Diversity in the responses of various immunocytes. In Annals of the New York Academy of Sciences. Vol. 1090. 2006. p. 161-167. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1378.017
Kiss, Endre ; Sármay, G. ; Matkó, J. / Ceramide modulation of antigen-triggered Ca2+ signals and cell fate : Diversity in the responses of various immunocytes. Annals of the New York Academy of Sciences. Vol. 1090 2006. pp. 161-167 (Annals of the New York Academy of Sciences).
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