Centromere proteins - I. Mitosis specific centromere antigen recognized by anti-centromere autoantibodies

Gyula Hadlaczky, Tunde Praznovszky, I. Raskó, Judit Kereso

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr=59000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive. In interphase nuclei, this centromere antigen was not detectable by immunoblot techniques. The results suggest that the Mr=59000 mitosis specific protein may be necessary for the structural stability of kinetochores during mitosis.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalChromosoma
Volume97
Issue number4
DOIs
Publication statusPublished - Jan 1989

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Centromere
Mitosis
Autoantibodies
Antigens
Proteins
Chromosomes
Kinetochores
Deoxyribonuclease I
Interphase
Fibroblasts
Serum

ASJC Scopus subject areas

  • Genetics

Cite this

Centromere proteins - I. Mitosis specific centromere antigen recognized by anti-centromere autoantibodies. / Hadlaczky, Gyula; Praznovszky, Tunde; Raskó, I.; Kereso, Judit.

In: Chromosoma, Vol. 97, No. 4, 01.1989, p. 282-288.

Research output: Contribution to journalArticle

Hadlaczky, Gyula ; Praznovszky, Tunde ; Raskó, I. ; Kereso, Judit. / Centromere proteins - I. Mitosis specific centromere antigen recognized by anti-centromere autoantibodies. In: Chromosoma. 1989 ; Vol. 97, No. 4. pp. 282-288.
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