Centromere proteins - I. Mitosis specific centromere antigen recognized by anti-centromere autoantibodies

Gyula Hadlaczky, Tunde Praznovszky, Istvan Rasko, Judit Kereso

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Abstract

Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr=59000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive. In interphase nuclei, this centromere antigen was not detectable by immunoblot techniques. The results suggest that the Mr=59000 mitosis specific protein may be necessary for the structural stability of kinetochores during mitosis.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalChromosoma
Volume97
Issue number4
DOIs
Publication statusPublished - Jan 1 1989

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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