Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus

György Nagy, A. Koncz, Tiffany Telarico, David Fernandez, Barbara Érsek, E. Búzás, András Perl

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Nitric oxide (NO) has been shown to regulate T cell functions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated in a variety of rheumatic diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Several studies reported increased endogenous NO synthesis in both SLE and RA, and recent evidence suggests that NO contributes to T cell dysfunction in both autoimmune diseases. The depletion of intracellular glutathione may be a key factor predisposing patients with SLE to mitochondrial dysfunction, characterized by mitochondrial hyperpolarization, ATP depletion and predisposition to death by necrosis. Thus, changes in glutathione metabolism may infl uence the eff ect of increased NO production in the pathogenesis of autoimmunity.

Original languageEnglish
Article number210
JournalArthritis Research and Therapy
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 7 2010

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Rheumatoid Arthritis
Nitric Oxide
Systemic Lupus Erythematosus
T-Lymphocytes
Glutathione
Rheumatic Diseases
Autoimmunity
Causality
Autoimmune Diseases
Necrosis
Adenosine Triphosphate
Wounds and Injuries

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus. / Nagy, György; Koncz, A.; Telarico, Tiffany; Fernandez, David; Érsek, Barbara; Búzás, E.; Perl, András.

In: Arthritis Research and Therapy, Vol. 12, No. 3, 210, 07.06.2010.

Research output: Contribution to journalArticle

Nagy, György ; Koncz, A. ; Telarico, Tiffany ; Fernandez, David ; Érsek, Barbara ; Búzás, E. ; Perl, András. / Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus. In: Arthritis Research and Therapy. 2010 ; Vol. 12, No. 3.
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