Central neuroendocrine mechanisms of gastroprotection

Research output: Contribution to journalArticle

Abstract

Selye recognized the importance of activation of hypothala-mic-pituitary- adrenal axis during stress and the connection between central nervous system and neuroendocrine regulation. This concept basically contributed to initiation of the studies, which revealed the importance of brain gut axis in regulation of gastric mucosal integrity. Several neuropeptides, such as thyreotrop releasing hormones, adrenomedullin, peptide YY, amylin, opioid peptides, noci-ceptin, nocisatin, substance P, ghrelin, leptin, orexin-A, angiotensin II were shown to induce gastroprotective effect injected centrally. Though the involvement of dorsal vagal complex and vagal nerves in conveying the central action to the periphery has been well documented, additional mechanisms have also been raised. The interaction between neuropeptides further component that may modify the gastric mucosal resistance to noxious stimulus.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalIdeggyógyászati szemle
Volume67
Issue number3-4
Publication statusPublished - Mar 3 2014

Fingerprint

Neuropeptides
Stomach
Peptide YY
Islet Amyloid Polypeptide
Adrenomedullin
Ghrelin
Opioid Peptides
Substance P
Leptin
Angiotensin II
Central Nervous System
Hormones
Brain
Orexins

Keywords

  • Gastroprotection
  • Hypothalamic-pituitary-adrenal axis
  • Neuropeptides

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Central neuroendocrine mechanisms of gastroprotection. / Gyires, K.

In: Ideggyógyászati szemle, Vol. 67, No. 3-4, 03.03.2014, p. 103-106.

Research output: Contribution to journalArticle

@article{09a4b3958b0a457fa2fb8c66ce2794c6,
title = "Central neuroendocrine mechanisms of gastroprotection",
abstract = "Selye recognized the importance of activation of hypothala-mic-pituitary- adrenal axis during stress and the connection between central nervous system and neuroendocrine regulation. This concept basically contributed to initiation of the studies, which revealed the importance of brain gut axis in regulation of gastric mucosal integrity. Several neuropeptides, such as thyreotrop releasing hormones, adrenomedullin, peptide YY, amylin, opioid peptides, noci-ceptin, nocisatin, substance P, ghrelin, leptin, orexin-A, angiotensin II were shown to induce gastroprotective effect injected centrally. Though the involvement of dorsal vagal complex and vagal nerves in conveying the central action to the periphery has been well documented, additional mechanisms have also been raised. The interaction between neuropeptides further component that may modify the gastric mucosal resistance to noxious stimulus.",
keywords = "Gastroprotection, Hypothalamic-pituitary-adrenal axis, Neuropeptides",
author = "K. Gyires",
year = "2014",
month = "3",
day = "3",
language = "English",
volume = "67",
pages = "103--106",
journal = "Ideggyogyaszati Szemle",
issn = "0019-1442",
publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",
number = "3-4",

}

TY - JOUR

T1 - Central neuroendocrine mechanisms of gastroprotection

AU - Gyires, K.

PY - 2014/3/3

Y1 - 2014/3/3

N2 - Selye recognized the importance of activation of hypothala-mic-pituitary- adrenal axis during stress and the connection between central nervous system and neuroendocrine regulation. This concept basically contributed to initiation of the studies, which revealed the importance of brain gut axis in regulation of gastric mucosal integrity. Several neuropeptides, such as thyreotrop releasing hormones, adrenomedullin, peptide YY, amylin, opioid peptides, noci-ceptin, nocisatin, substance P, ghrelin, leptin, orexin-A, angiotensin II were shown to induce gastroprotective effect injected centrally. Though the involvement of dorsal vagal complex and vagal nerves in conveying the central action to the periphery has been well documented, additional mechanisms have also been raised. The interaction between neuropeptides further component that may modify the gastric mucosal resistance to noxious stimulus.

AB - Selye recognized the importance of activation of hypothala-mic-pituitary- adrenal axis during stress and the connection between central nervous system and neuroendocrine regulation. This concept basically contributed to initiation of the studies, which revealed the importance of brain gut axis in regulation of gastric mucosal integrity. Several neuropeptides, such as thyreotrop releasing hormones, adrenomedullin, peptide YY, amylin, opioid peptides, noci-ceptin, nocisatin, substance P, ghrelin, leptin, orexin-A, angiotensin II were shown to induce gastroprotective effect injected centrally. Though the involvement of dorsal vagal complex and vagal nerves in conveying the central action to the periphery has been well documented, additional mechanisms have also been raised. The interaction between neuropeptides further component that may modify the gastric mucosal resistance to noxious stimulus.

KW - Gastroprotection

KW - Hypothalamic-pituitary-adrenal axis

KW - Neuropeptides

UR - http://www.scopus.com/inward/record.url?scp=84899825802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899825802&partnerID=8YFLogxK

M3 - Article

VL - 67

SP - 103

EP - 106

JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

SN - 0019-1442

IS - 3-4

ER -