Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: A report of two cases

Nóra Eros, Márta Marschalko, Katalin Balassa, Bernadett Hídvégi, József Szakonyi, Sándor Ilniczky, Katalin Borka, Attila Kovács, Gyula Bottlik, Judit Hársing, Judit Csomor, Ágota Szepesi, András Matolcsy, Sarolta Kárpáti, Judit Demeter

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5 Citations (Scopus)


CD4+/CD56+hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalJournal of Neuro-Oncology
Issue number2
Publication statusPublished - Apr 1 2010



  • Blastic NK-cell lymphoma
  • CD4+/CD56+ hematodermic neoplasm
  • Central nervous system involvement
  • Cerebrospinal fluid analysis
  • Prophylactic intrathecal chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Eros, N., Marschalko, M., Balassa, K., Hídvégi, B., Szakonyi, J., Ilniczky, S., Borka, K., Kovács, A., Bottlik, G., Hársing, J., Csomor, J., Szepesi, Á., Matolcsy, A., Kárpáti, S., & Demeter, J. (2010). Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: A report of two cases. Journal of Neuro-Oncology, 97(2), 301-304. https://doi.org/10.1007/s11060-009-0026-y