Central hypothyroidism is associated with advanced age in male fischer 344/N rats: In vivo and in vitro studies

Giovanni Cizza, Linda S. Brady, Aldo E. Calogero, G. Bagdy, Allyson B. Lynn, Mitchel A. Kling, Marc R. Blackman, George P. Chrousos, Philip W. Gold

Research output: Contribution to journalArticle

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Abstract

We investigated age-related alterations in hypothalamic-pituitary-thyroid function in a series of in vivo and in vitro studies in 2-, 8-, 18-, and 24-month-old male Fischer 344/N (F344/N) rats. Thyroid histology showed progressive follicular loss with advancing age; this was associated with significant and progressive decrements in plasma levels of free T4 and free T3, but not immunoreactive TSH, which remained unchanged with age. This was accompanied by a progressive age-dependent loss in in vivo responsivity of the thyrotroph to synthetic TRH and a paradoxically augmented response of GH to this peptide in the oldest rats. Steady state levels of prepro-TRH mRNA in the hypothalamic paraventricular nucleus were decreased with age, whereas TRH content in and in vitro secretion by whole hypothalami remained unchanged. Both anterior pituitary steady state TSH β-subunit mRNA levels and TSH content were decreased with age. Taken together, these data suggest that aging in male F344/N rats is associated with a progressive, centrally mediated decrease in thyroid function. The relative contributions to this phenomenon of age-related alterations in suprahypothalamic and/or hypothalamic vs. pituitary thyrotropic function remain to be determined, as do the relationship? between changes in hypothalamic-pituitary-thyroid function and those in aging per se.

Original languageEnglish
Pages (from-to)2672-2680
Number of pages9
JournalEndocrinology
Volume131
Issue number6
Publication statusPublished - Dec 1992

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Hypothyroidism
Thyroid Gland
Thyrotrophs
Messenger RNA
Paraventricular Hypothalamic Nucleus
Hypothalamus
Histology
Peptides
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cizza, G., Brady, L. S., Calogero, A. E., Bagdy, G., Lynn, A. B., Kling, M. A., ... Gold, P. W. (1992). Central hypothyroidism is associated with advanced age in male fischer 344/N rats: In vivo and in vitro studies. Endocrinology, 131(6), 2672-2680.

Central hypothyroidism is associated with advanced age in male fischer 344/N rats : In vivo and in vitro studies. / Cizza, Giovanni; Brady, Linda S.; Calogero, Aldo E.; Bagdy, G.; Lynn, Allyson B.; Kling, Mitchel A.; Blackman, Marc R.; Chrousos, George P.; Gold, Philip W.

In: Endocrinology, Vol. 131, No. 6, 12.1992, p. 2672-2680.

Research output: Contribution to journalArticle

Cizza, G, Brady, LS, Calogero, AE, Bagdy, G, Lynn, AB, Kling, MA, Blackman, MR, Chrousos, GP & Gold, PW 1992, 'Central hypothyroidism is associated with advanced age in male fischer 344/N rats: In vivo and in vitro studies', Endocrinology, vol. 131, no. 6, pp. 2672-2680.
Cizza, Giovanni ; Brady, Linda S. ; Calogero, Aldo E. ; Bagdy, G. ; Lynn, Allyson B. ; Kling, Mitchel A. ; Blackman, Marc R. ; Chrousos, George P. ; Gold, Philip W. / Central hypothyroidism is associated with advanced age in male fischer 344/N rats : In vivo and in vitro studies. In: Endocrinology. 1992 ; Vol. 131, No. 6. pp. 2672-2680.
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