Central corneal thickness measurements with optical coherence tomography and ultrasound pachymetry in healthy subjects and in patiens after photorefractive keratectomy

Miklos Schneider, Gabor Borgulya, Andras Seres, Zoltan Z. Nagy, J. Németh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purposse. To compare central corneal thickness measurements made using two different methods, optical coherence tomography (OCT) and ultrasound pachymetry, applied both in normal eyes and in eyes on which photorefractive keratectomy (PRK) had been performed. A second objective was to assess the intrasession variability of OCT measurements. Methods. In this prospective study, central corneal thickness was measured in 20 normal subjects (normal group) and in 20 PRK patients using the StratusOCT instrument model 3000 (Carl Zeiss Meditec), and also with an ultrasound pachymeter. Five OCT measurements were performed using the Fast Macular Thickness protocol. Corneal thickness data were obtained with the Scan Profile analysis protocol. The OCT measurement results were compared with the mean value of three ultrasound pachymetry measurements for the same eye. Results. The pachymetry-OCT correlation coefficients were 0.96 and 0.97 in the normal and PRK groups, respectively (p=0.14). Neither linear regression nor Bland-Altmann analysis revealed any significant systematic measurement error. Intrasession standard deviations in the normal and PRK groups were 4.9 μm and 3.8 μm, respectively. Conclusions. Noncontact central corneal thickness measurements made using the StratusOCT instrument are accurate and reproducible, both in normal subjects and in post-PRK patients. The instrument system does not need any modifications to correctly detect and measure the center of the cornea.

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalEuropean Journal of Ophthalmology
Volume19
Issue number2
Publication statusPublished - 2009

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Corneal Pachymetry
Photorefractive Keratectomy
Optical Coherence Tomography
Healthy Volunteers
Cornea
Linear Models
Prospective Studies

Keywords

  • Central corneal thickness
  • Optical coherence tomography
  • Pachymetry
  • Photorefractive keratectomy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Central corneal thickness measurements with optical coherence tomography and ultrasound pachymetry in healthy subjects and in patiens after photorefractive keratectomy. / Schneider, Miklos; Borgulya, Gabor; Seres, Andras; Nagy, Zoltan Z.; Németh, J.

In: European Journal of Ophthalmology, Vol. 19, No. 2, 2009, p. 180-187.

Research output: Contribution to journalArticle

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AU - Nagy, Zoltan Z.

AU - Németh, J.

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AB - Purposse. To compare central corneal thickness measurements made using two different methods, optical coherence tomography (OCT) and ultrasound pachymetry, applied both in normal eyes and in eyes on which photorefractive keratectomy (PRK) had been performed. A second objective was to assess the intrasession variability of OCT measurements. Methods. In this prospective study, central corneal thickness was measured in 20 normal subjects (normal group) and in 20 PRK patients using the StratusOCT instrument model 3000 (Carl Zeiss Meditec), and also with an ultrasound pachymeter. Five OCT measurements were performed using the Fast Macular Thickness protocol. Corneal thickness data were obtained with the Scan Profile analysis protocol. The OCT measurement results were compared with the mean value of three ultrasound pachymetry measurements for the same eye. Results. The pachymetry-OCT correlation coefficients were 0.96 and 0.97 in the normal and PRK groups, respectively (p=0.14). Neither linear regression nor Bland-Altmann analysis revealed any significant systematic measurement error. Intrasession standard deviations in the normal and PRK groups were 4.9 μm and 3.8 μm, respectively. Conclusions. Noncontact central corneal thickness measurements made using the StratusOCT instrument are accurate and reproducible, both in normal subjects and in post-PRK patients. The instrument system does not need any modifications to correctly detect and measure the center of the cornea.

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