Central atrial natriuretic peptide in dehydration.

Udo Bahner, Helmut Geiger, Miklós Palkovits, Zsolt Lenkei, Friedrich C. Luft, August Heidland

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To test the effect of dehydration on brain atrial natriuretic peptide (ANP) concentrations in areas important to salt appetite, water balance and cardiovascular regulation, we subjected rats to dehydration and rehydration and measured ANP concentration in 18 brain areas, as well as all relevant peripheral parameters. Water deprivation decreased body weight, blood pressure, urine volume, and plasma ANP, while it increased urine and plasma osmolality, angiotensin II, and vasopressin. ANP greatly increased in 17 and 18 brain areas (all cut cerebral cortex) by 24 h. Rehydration for 12 h corrected all changes evoked by dehydration, including elevated ANP levels in brain. We conclude that chronic dehydration results in increased ANP in brain areas important to salt appetite and water balance. These results support a role for ANP as a neuroregulatory substance that participates in salt and water balance.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalIdeggyógyászati szemle
Volume60
Issue number3-4
Publication statusPublished - Mar 30 2007

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Bahner, U., Geiger, H., Palkovits, M., Lenkei, Z., Luft, F. C., & Heidland, A. (2007). Central atrial natriuretic peptide in dehydration. Ideggyógyászati szemle, 60(3-4), 130-135.