Central alpha-MSH infusion in rats: Disparate anorexic vs. Metabolic changes with aging

E. Pétervári, A. O. Szabad, S. Soós, A. Garami, M. Székely, M. Balaskó

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Changes of the anorexigenic and hypermetabolic components of the overall catabolic effect of alpha-MSH were studied in rats as a function of age. In male Wistar rats a 7. day-long intracerebroventricular infusion of alpha-MSH suppressed food intake and caused a fall in body weight in 2 and 3-4. month-old (young) groups, but it was most effective in the 24. month-old group and had hardly any effect in the 12. month-old (middle-aged) animals. In contrast, metabolic rate as well as biotelemetric measurements of core temperature and heart rate revealed the most pronounced hypermetabolic effects of such infusions at age 12. months. The hypermetabolic effect was still high in the oldest group, but low in the younger groups. In conclusion: Changes of the anorexigenic and hypermetabolic effects in the course of aging are not concordant. The overall catabolic activity of alpha-MSH is smallest in the middle-aged and highest in the oldest group.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalRegulatory Peptides
Volume166
Issue number1-3
DOIs
Publication statusPublished - Jan 17 2011

Keywords

  • Biotelemetry
  • Body temperature
  • Body weight
  • Catabolic peptide
  • Food intake
  • Heart rate

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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