Cellular networks and the aging process

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. After a brief introduction to cellular networks (protein-protein interaction networks, metabolic networks, gene regulatory networks, signalling networks and membrane-organelle networks) an overview is given on the network aspects of the theories on aging. The most important part of the review summarizes our knowledge on the aging of networks. The effects of aging on the general network models are described, as well as the initial findings on the effects of aging on the cellular networks. Finally we suggest a 'weak link theory of aging' linking the random damage of the network constituents to the overwhelming majority of the low affinity, transient interactions (weak links) in the cellular networks. We show that random damage of weak links may lead to an increase of noise and an increased vulnerability of cellular networks, and make a comparison between these predictions and the observed behaviour of the emergent properties of cellular networks in aged organisms.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalArchives of Physiology and Biochemistry
Volume112
Issue number2
DOIs
Publication statusPublished - Apr 1 2006

Fingerprint

Protein Interaction Maps
Gene Regulatory Networks
Cell Aging
Metabolic Networks and Pathways
Organelles
Noise
Aging of materials
Membranes
Proteins
Genes
Molecules

Keywords

  • Aging
  • Network integrity
  • Protein-protein interaction network
  • Signalling network
  • Transcriptional regulatory network

ASJC Scopus subject areas

  • Physiology
  • Biochemistry

Cite this

Cellular networks and the aging process. / Csermely, P.; Söti, C.

In: Archives of Physiology and Biochemistry, Vol. 112, No. 2, 01.04.2006, p. 60-64.

Research output: Contribution to journalArticle

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