A máj sejtszintú és molekuláris eltérései szepszisben és szisztémás gyulladásos válaszreakció (SIRS) szindrómában.

Translated title of the contribution: Cellular and molecular changes of the liver in sepsis and in systemic inflammatory response syndrome (SIRS)

László Romics, György Frendl, G. Szabó

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

This paper provides a review on the changes in the molecular and cellular level of the liver during sepsis and systemic immune response syndrome. The different function of the various liver cells and their mediators are analyzed. Dual role of nitric-oxide and carbon-monoxide are discussed followed by an overview about acute phase proteins and heat shock proteins in septic liver. A detailed description is presented on the role of the Toll-like receptors and their signaling pathways in the liver during sepsis and systemic immune response syndrome. Finally, the possible mechanisms leading to apoptosis of the liver cells are shown and the most recent therapeutical challenges are discussed.

Original languageHungarian
Pages (from-to)499-506
Number of pages8
JournalOrvosi Hetilap
Volume144
Issue number11
Publication statusPublished - Mar 16 2003

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Systemic Inflammatory Response Syndrome
Sepsis
Liver
Acute-Phase Proteins
Toll-Like Receptors
Carbon Monoxide
Heat-Shock Proteins
Nitric Oxide
Apoptosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A máj sejtszintú és molekuláris eltérései szepszisben és szisztémás gyulladásos válaszreakció (SIRS) szindrómában. / Romics, László; Frendl, György; Szabó, G.

In: Orvosi Hetilap, Vol. 144, No. 11, 16.03.2003, p. 499-506.

Research output: Contribution to journalReview article

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abstract = "This paper provides a review on the changes in the molecular and cellular level of the liver during sepsis and systemic immune response syndrome. The different function of the various liver cells and their mediators are analyzed. Dual role of nitric-oxide and carbon-monoxide are discussed followed by an overview about acute phase proteins and heat shock proteins in septic liver. A detailed description is presented on the role of the Toll-like receptors and their signaling pathways in the liver during sepsis and systemic immune response syndrome. Finally, the possible mechanisms leading to apoptosis of the liver cells are shown and the most recent therapeutical challenges are discussed.",
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