Abstract
This paper provides a review on the changes in the molecular and cellular level of the liver during sepsis and systemic immune response syndrome. The different function of the various liver cells and their mediators are analyzed. Dual role of nitric-oxide and carbon-monoxide are discussed followed by an overview about acute phase proteins and heat shock proteins in septic liver. A detailed description is presented on the role of the Toll-like receptors and their signaling pathways in the liver during sepsis and systemic immune response syndrome. Finally, the possible mechanisms leading to apoptosis of the liver cells are shown and the most recent therapeutical challenges are discussed.
Original language | Hungarian |
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Pages (from-to) | 499-506 |
Number of pages | 8 |
Journal | Orvosi Hetilap |
Volume | 144 |
Issue number | 11 |
Publication status | Published - Mar 16 2003 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
A máj sejtszintú és molekuláris eltérései szepszisben és szisztémás gyulladásos válaszreakció (SIRS) szindrómában. / Romics, László; Frendl, György; Szabó, G.
In: Orvosi Hetilap, Vol. 144, No. 11, 16.03.2003, p. 499-506.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - A máj sejtszintú és molekuláris eltérései szepszisben és szisztémás gyulladásos válaszreakció (SIRS) szindrómában.
AU - Romics, László
AU - Frendl, György
AU - Szabó, G.
PY - 2003/3/16
Y1 - 2003/3/16
N2 - This paper provides a review on the changes in the molecular and cellular level of the liver during sepsis and systemic immune response syndrome. The different function of the various liver cells and their mediators are analyzed. Dual role of nitric-oxide and carbon-monoxide are discussed followed by an overview about acute phase proteins and heat shock proteins in septic liver. A detailed description is presented on the role of the Toll-like receptors and their signaling pathways in the liver during sepsis and systemic immune response syndrome. Finally, the possible mechanisms leading to apoptosis of the liver cells are shown and the most recent therapeutical challenges are discussed.
AB - This paper provides a review on the changes in the molecular and cellular level of the liver during sepsis and systemic immune response syndrome. The different function of the various liver cells and their mediators are analyzed. Dual role of nitric-oxide and carbon-monoxide are discussed followed by an overview about acute phase proteins and heat shock proteins in septic liver. A detailed description is presented on the role of the Toll-like receptors and their signaling pathways in the liver during sepsis and systemic immune response syndrome. Finally, the possible mechanisms leading to apoptosis of the liver cells are shown and the most recent therapeutical challenges are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0038043337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038043337&partnerID=8YFLogxK
M3 - Review article
C2 - 12731336
AN - SCOPUS:0038043337
VL - 144
SP - 499
EP - 506
JO - Orvosi Hetilap
JF - Orvosi Hetilap
SN - 0030-6002
IS - 11
ER -