Cellular and humoral autoimmune responses against human eye muscle membrane antigen in Graves' disease.

I. Molnár, K. Németi, A. Bokk, V. Stenszky, C. Balázs, N. R. Farid

Research output: Contribution to journalArticle

Abstract

75 patients with Graves' disease (54 with ophthalmopathy) were investigated using the tests of leucocyte adherence inhibition and immune adsorption with 125I-labelled Staphylococcus Protein A, against human eye muscle "crude" membrane antigen. The results of positive leucocyte adherence inhibition (10 out of 26 vs. 1 out of 28, P less than 0.05) and anti-human eye muscle membrane antibody index (mean +/- S.D.) (1.89 +/- 1.20 vs. 0.84 +/- 0.38, P less than 0.001) showed a correlation with the patients with clinically active eye disease and the HLA-B8 antigen in Graves' ophthalmopathy (P less than 0.01). Positive leucocyte adherence inhibition was observed in 9 out of 21 cases of Graves' disease without ophthalmopathy, but its prognostic relevance has to be confirmed in the development of ophthalmopathy.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalActa Medica Hungarica
Volume47
Issue number1-2
Publication statusPublished - 1990

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Graves Disease
Autoimmunity
Leukocyte Adherence Inhibition Test
Leukocytes
HLA-B8 Antigen
Graves Ophthalmopathy
Antigens
Muscles
Membranes
Eye Diseases
Staphylococcal Protein A
Staphylococcus
Adsorption
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molnár, I., Németi, K., Bokk, A., Stenszky, V., Balázs, C., & Farid, N. R. (1990). Cellular and humoral autoimmune responses against human eye muscle membrane antigen in Graves' disease. Acta Medica Hungarica, 47(1-2), 43-51.

Cellular and humoral autoimmune responses against human eye muscle membrane antigen in Graves' disease. / Molnár, I.; Németi, K.; Bokk, A.; Stenszky, V.; Balázs, C.; Farid, N. R.

In: Acta Medica Hungarica, Vol. 47, No. 1-2, 1990, p. 43-51.

Research output: Contribution to journalArticle

Molnár, I, Németi, K, Bokk, A, Stenszky, V, Balázs, C & Farid, NR 1990, 'Cellular and humoral autoimmune responses against human eye muscle membrane antigen in Graves' disease.', Acta Medica Hungarica, vol. 47, no. 1-2, pp. 43-51.
Molnár, I. ; Németi, K. ; Bokk, A. ; Stenszky, V. ; Balázs, C. ; Farid, N. R. / Cellular and humoral autoimmune responses against human eye muscle membrane antigen in Graves' disease. In: Acta Medica Hungarica. 1990 ; Vol. 47, No. 1-2. pp. 43-51.
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