Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

Kai Du, Yu Wei Wu, Robert Lindroos, Yu Liu, B. Rózsa, Gergely Katona, Jun B. Ding, Jeanette Hellgren Kotaleski

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Striatal spiny projection neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex and thalamus. Activation of spatially clustered and temporally synchronized excitatory inputs at the distal dendrites could trigger plateau potentials in SPNs. Such supralinear synaptic integration is crucial for dendritic computation. However, how plateau potentials interact with subsequent excitatory and inhibitory synaptic inputs remains unknown. By combining computational simulation, two-photon imaging, optogenetics, and dual-color uncaging of glutamate and GABA, we demonstrate that plateau potentials can broaden the spatiotemporal window for integrating excitatory inputs and promote spiking. The temporal window of spiking can be delicately controlled by GABAergic inhibition in a cell-type–specific manner. This subtle inhibitory control of plateau potential depends on the location and kinetics of the GABAergic inputs and is achieved by the balance between relief and reestablishment of NMDA receptor Mg2+ block. These findings represent a mechanism for controlling spatiotemporal synaptic integration in SPNs.

Original languageEnglish
Pages (from-to)E7612-E7621
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number36
DOIs
Publication statusPublished - Sep 5 2017

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Corpus Striatum
Neurons
Optogenetics
Dendrites
N-Methyl-D-Aspartate Receptors
Thalamus
Photons
gamma-Aminobutyric Acid
Glutamic Acid
Color

Keywords

  • Dendritic computation
  • Inhibition
  • Plateau potential
  • Striatum
  • Synaptic integration

ASJC Scopus subject areas

  • General

Cite this

Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. / Du, Kai; Wu, Yu Wei; Lindroos, Robert; Liu, Yu; Rózsa, B.; Katona, Gergely; Ding, Jun B.; Kotaleski, Jeanette Hellgren.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 36, 05.09.2017, p. E7612-E7621.

Research output: Contribution to journalArticle

Du, Kai ; Wu, Yu Wei ; Lindroos, Robert ; Liu, Yu ; Rózsa, B. ; Katona, Gergely ; Ding, Jun B. ; Kotaleski, Jeanette Hellgren. / Cell-type–specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. In: Proceedings of the National Academy of Sciences of the United States of America. 2017 ; Vol. 114, No. 36. pp. E7612-E7621.
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