Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones

Attila Losonczy, Limei Zhang, Ryuichi Shigemoto, Peter Somogyi, Z. Nusser

Research output: Contribution to journalArticle

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Abstract

Synapses exhibit different short-term plasticity patterns and this behaviour influences information processing in neuronal networks. We tested how the short-term plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic cell type, identified by axonal arborizations and molecular markers in the hippocampal CA1 area. Three distinct types of short-term synaptic behaviour (facilitating, depressing and combined facilitating-depressing) were defined by fitting a dynamic neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a positive axon terminals. Responses in eight of 12 basket cells were described well with a model involving only depression, but the other cells displayed combined facilitating-depressing EPSCs. No apparent difference was found between the plasticity of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing, and the remaining five cells combined facilitating-depressing EPSCs. Seven of 10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic responses to action potentials recorded in vivo from a CA1 place cell were modelled, and revealed great differences between and within cell types. Our results demonstrate that the short-term plasticity of EPSCs is cell type dependent, but with significant heterogeneity within all three interneurone populations.

Original languageEnglish
Pages (from-to)193-210
Number of pages18
JournalJournal of Physiology
Volume542
Issue number1
DOIs
Publication statusPublished - Jul 1 2002

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Excitatory Postsynaptic Potentials
Interneurons
Hippocampus
Depression
Parvalbumins
Somatostatin-Secreting Cells
Cholecystokinin
Presynaptic Terminals
Somatostatin
Automatic Data Processing
Synaptic Transmission
Synapses
Action Potentials

ASJC Scopus subject areas

  • Physiology

Cite this

Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. / Losonczy, Attila; Zhang, Limei; Shigemoto, Ryuichi; Somogyi, Peter; Nusser, Z.

In: Journal of Physiology, Vol. 542, No. 1, 01.07.2002, p. 193-210.

Research output: Contribution to journalArticle

Losonczy, Attila ; Zhang, Limei ; Shigemoto, Ryuichi ; Somogyi, Peter ; Nusser, Z. / Cell type dependence and variability in the short-term plasticity of EPSCs in identified mouse hippocampal interneurones. In: Journal of Physiology. 2002 ; Vol. 542, No. 1. pp. 193-210.
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