The surface properties of vincristine-colchicine sensitive and resistant L1210 leukemic cells were studied using concanavalin A mediated agglutination assay as well as electron microscopic visualization of concanavalin A receptors. 3H-colchicine uptake by the sensitive and resistant lines was also compared. The resistant L1210 leukemic cells proved less agglutinable than the sensitive ones at the same concanavalin A concentration. Previous treatments with either colchicine, vincristine or chlorpromazine caused a marked decrease in the agglutinability of the sensitive L1210 leukemic cells, while agglutination of the resistant ones was lowered slightly by the same treatments. The 3H-colchicine uptake of the sensitive cells was 3 times higher than that of the resistant ones.
|Number of pages||9|
|Journal||Acta morphologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1976|
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