Cell resolved, multiparticle model of plastic tissue deformations and morphogenesis

A. Czirók, Dona Greta Isai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We propose a three-dimensional mechanical model of embryonic tissue dynamics. Mechanically coupled adherent cells are represented as particles interconnected with elastic beams which can exert non-central forces and torques. Tissue plasticity is modeled by a stochastic process consisting of a connectivity change (addition or removal of a single link) followed by a complete relaxation to mechanical equilibrium. In particular, we assume that (i) two non-connected, but adjacent particles can form a new link; and (ii) the lifetime of links is reduced by tensile forces. We demonstrate that the proposed model yields a realistic macroscopic elasto-plastic behavior and we establish how microscopic model parameters determine material properties at the macroscopic scale. Based on these results, microscopic parameter values can be inferred from tissue thickness, macroscopic elastic modulus and the magnitude and dynamics of intercellular adhesion forces. In addition to their mechanical role, model particles can also act as simulation agents and actively modulate their connectivity according to specific rules. As an example, anisotropic link insertion and removal probabilities can give rise to local cell intercalation and large scale convergent extension movements. The proposed stochastic simulation of cell activities yields fluctuating tissue movements which exhibit the same autocorrelation properties as empirical data from avian embryos.

Original languageEnglish
Article number016005
JournalPhysical Biology
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 1 2015

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Morphogenesis
Stochastic Processes
Elastic Modulus
Torque
Plastics
Embryonic Structures

Keywords

  • cell motility
  • convergent-extension
  • elasto-plastic model
  • tissue morphogenesis
  • tissue motion

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Structural Biology

Cite this

Cell resolved, multiparticle model of plastic tissue deformations and morphogenesis. / Czirók, A.; Isai, Dona Greta.

In: Physical Biology, Vol. 12, No. 1, 016005, 01.02.2015.

Research output: Contribution to journalArticle

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