Az agykéregben és a kisagyban az idegsejtek képzodését a genetikus kor határozza meg, és a születés idopontja nem befolyásolja

(Ö sszehasonlító vizsgálat koraszülött és terminusra született csecsemokben)

Translated title of the contribution: Cell proliferation of the cerebral cortex and cerebellum is a genetically controlled event and it is not influenced by preterm delivery (Comparative study in preterms and infants born at term)

Research output: Contribution to journalArticle

Abstract

Background: In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of the cerebellum and the hippocampus. A possible reason for reduction would be the reduced cell formation following premature birth. However, no data are available about the rate of postnatal cell proliferation in the different brain areas of preterms. Methods: Cytoarchitectonics and cell proliferation were examined in the cerebellum, hippocampal formation and the temporal neocortex of preterm infants who lived for several weeks or months. Cell proliferation was detected with Ki-67 (MIB-1) immunostaining and proliferating glial cells were identified with vimentin and the capillary wall with CD31 and periodic acid - Schiff reaction. Results: The rate of cell formation and the width of the cytoarchitectonic layers of the cerebellum of preterm infants corresponded to that of the age-matched controls. In the hippocampal dentate gyrus the rate of cell formation and the density of proliferating cells were slightly higher in the preterm infants than in the full-term age-matched controls. Endothelial cell proliferation and the surface area of the capillaries were larger in the dentate gyrus of preterms than in age-matched controls. Conclusion: The rate of cell proliferation that correlates with the postconceptual age is not reduced in the preterms, therefore the reduced size of the cerebellum and hippocampal formation is unlikely to be the result of decreased cell formation.

Original languageHungarian
Pages (from-to)363-370
Number of pages8
JournalMagyar Noorvosok Lapja
Volume67
Issue number6
Publication statusPublished - 2004

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Premature Infants
Cerebral Cortex
Cerebellum
Cell Proliferation
Hippocampus
Dentate Gyrus
Periodic Acid-Schiff Reaction
Parahippocampal Gyrus
Neocortex
Premature Birth
Vimentin
Neuroglia
Endothelial Cells
Cell Count
Brain

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{8ec8a843e40541c7a0791120af2114fc,
title = "Az agyk{\'e}regben {\'e}s a kisagyban az idegsejtek k{\'e}pzod{\'e}s{\'e}t a genetikus kor hat{\'a}rozza meg, {\'e}s a sz{\"u}let{\'e}s idopontja nem befoly{\'a}solja: ({\"O} sszehasonl{\'i}t{\'o} vizsg{\'a}lat korasz{\"u}l{\"o}tt {\'e}s terminusra sz{\"u}letett csecsemokben)",
abstract = "Background: In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of the cerebellum and the hippocampus. A possible reason for reduction would be the reduced cell formation following premature birth. However, no data are available about the rate of postnatal cell proliferation in the different brain areas of preterms. Methods: Cytoarchitectonics and cell proliferation were examined in the cerebellum, hippocampal formation and the temporal neocortex of preterm infants who lived for several weeks or months. Cell proliferation was detected with Ki-67 (MIB-1) immunostaining and proliferating glial cells were identified with vimentin and the capillary wall with CD31 and periodic acid - Schiff reaction. Results: The rate of cell formation and the width of the cytoarchitectonic layers of the cerebellum of preterm infants corresponded to that of the age-matched controls. In the hippocampal dentate gyrus the rate of cell formation and the density of proliferating cells were slightly higher in the preterm infants than in the full-term age-matched controls. Endothelial cell proliferation and the surface area of the capillaries were larger in the dentate gyrus of preterms than in age-matched controls. Conclusion: The rate of cell proliferation that correlates with the postconceptual age is not reduced in the preterms, therefore the reduced size of the cerebellum and hippocampal formation is unlikely to be the result of decreased cell formation.",
keywords = "Brain development, Fetal neuronal cell formation, Perinatal care",
author = "H. {\'A}brah{\'a}m and B{\'e}la Veszpr{\'e}mi and T. Torn{\'o}czky and G. Kosztol{\'a}nyi and L. S{\'e}ress",
year = "2004",
language = "Hungarian",
volume = "67",
pages = "363--370",
journal = "Magyar Noorvosok Lapja",
issn = "0025-021X",
publisher = "Magyar Noovos Tarsasag",
number = "6",

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TY - JOUR

T1 - Az agykéregben és a kisagyban az idegsejtek képzodését a genetikus kor határozza meg, és a születés idopontja nem befolyásolja

T2 - (Ö sszehasonlító vizsgálat koraszülött és terminusra született csecsemokben)

AU - Ábrahám, H.

AU - Veszprémi, Béla

AU - Tornóczky, T.

AU - Kosztolányi, G.

AU - Séress, L.

PY - 2004

Y1 - 2004

N2 - Background: In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of the cerebellum and the hippocampus. A possible reason for reduction would be the reduced cell formation following premature birth. However, no data are available about the rate of postnatal cell proliferation in the different brain areas of preterms. Methods: Cytoarchitectonics and cell proliferation were examined in the cerebellum, hippocampal formation and the temporal neocortex of preterm infants who lived for several weeks or months. Cell proliferation was detected with Ki-67 (MIB-1) immunostaining and proliferating glial cells were identified with vimentin and the capillary wall with CD31 and periodic acid - Schiff reaction. Results: The rate of cell formation and the width of the cytoarchitectonic layers of the cerebellum of preterm infants corresponded to that of the age-matched controls. In the hippocampal dentate gyrus the rate of cell formation and the density of proliferating cells were slightly higher in the preterm infants than in the full-term age-matched controls. Endothelial cell proliferation and the surface area of the capillaries were larger in the dentate gyrus of preterms than in age-matched controls. Conclusion: The rate of cell proliferation that correlates with the postconceptual age is not reduced in the preterms, therefore the reduced size of the cerebellum and hippocampal formation is unlikely to be the result of decreased cell formation.

AB - Background: In previous studies, lower IQ scores and educational difficulties of preterm children were correlated with the reduced size of the cerebellum and the hippocampus. A possible reason for reduction would be the reduced cell formation following premature birth. However, no data are available about the rate of postnatal cell proliferation in the different brain areas of preterms. Methods: Cytoarchitectonics and cell proliferation were examined in the cerebellum, hippocampal formation and the temporal neocortex of preterm infants who lived for several weeks or months. Cell proliferation was detected with Ki-67 (MIB-1) immunostaining and proliferating glial cells were identified with vimentin and the capillary wall with CD31 and periodic acid - Schiff reaction. Results: The rate of cell formation and the width of the cytoarchitectonic layers of the cerebellum of preterm infants corresponded to that of the age-matched controls. In the hippocampal dentate gyrus the rate of cell formation and the density of proliferating cells were slightly higher in the preterm infants than in the full-term age-matched controls. Endothelial cell proliferation and the surface area of the capillaries were larger in the dentate gyrus of preterms than in age-matched controls. Conclusion: The rate of cell proliferation that correlates with the postconceptual age is not reduced in the preterms, therefore the reduced size of the cerebellum and hippocampal formation is unlikely to be the result of decreased cell formation.

KW - Brain development

KW - Fetal neuronal cell formation

KW - Perinatal care

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M3 - Article

VL - 67

SP - 363

EP - 370

JO - Magyar Noorvosok Lapja

JF - Magyar Noorvosok Lapja

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