Cell population kinetics, biochemical, ultrastructural changes occurring during growth of experimental tumors and their relevance to cancer chemotherapy

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Abstract

It was reported in several papers cited by the author and confirmed in model experiments in vitro, that simple hexoses, especially glucose, act as carcinostatic factors in liver homogenates. pH values from 5 to 5.5 were measured in resting tumor cell suspensions in the presence of such hexoses, but the strong carcinostatic effect could not be substantiated by an incubation of 37°C for 1 hr. In the present work it was shown by the aid of pH microelectrodes, that the pH value is 1.2 units lower in the cell sediment of about 3 mm thickness than in the supernatant. This result and further findings (e.g. transplantation experiments) reveal, that the carcinostatic effect of hexoses in the model experiments and with them the carcinostatic effect of the hypothetic liver factor is solely due to the hyperacidification. These results confirm the author's previous findings and the importance of optimal tumor hyperacidification within the multi stage cancer therapy concept.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalArchiv fur Geschwulstforschung
Volume42
Issue number3
Publication statusPublished - 1973

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Hexoses
Drug Therapy
Growth
Population
Neoplasms
Liver
Microelectrodes
Suspensions
Transplantation
Glucose
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

Cite this

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title = "Cell population kinetics, biochemical, ultrastructural changes occurring during growth of experimental tumors and their relevance to cancer chemotherapy",
abstract = "It was reported in several papers cited by the author and confirmed in model experiments in vitro, that simple hexoses, especially glucose, act as carcinostatic factors in liver homogenates. pH values from 5 to 5.5 were measured in resting tumor cell suspensions in the presence of such hexoses, but the strong carcinostatic effect could not be substantiated by an incubation of 37°C for 1 hr. In the present work it was shown by the aid of pH microelectrodes, that the pH value is 1.2 units lower in the cell sediment of about 3 mm thickness than in the supernatant. This result and further findings (e.g. transplantation experiments) reveal, that the carcinostatic effect of hexoses in the model experiments and with them the carcinostatic effect of the hypothetic liver factor is solely due to the hyperacidification. These results confirm the author's previous findings and the importance of optimal tumor hyperacidification within the multi stage cancer therapy concept.",
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AU - Kópper, L.

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N2 - It was reported in several papers cited by the author and confirmed in model experiments in vitro, that simple hexoses, especially glucose, act as carcinostatic factors in liver homogenates. pH values from 5 to 5.5 were measured in resting tumor cell suspensions in the presence of such hexoses, but the strong carcinostatic effect could not be substantiated by an incubation of 37°C for 1 hr. In the present work it was shown by the aid of pH microelectrodes, that the pH value is 1.2 units lower in the cell sediment of about 3 mm thickness than in the supernatant. This result and further findings (e.g. transplantation experiments) reveal, that the carcinostatic effect of hexoses in the model experiments and with them the carcinostatic effect of the hypothetic liver factor is solely due to the hyperacidification. These results confirm the author's previous findings and the importance of optimal tumor hyperacidification within the multi stage cancer therapy concept.

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