Zellproliferation und zelltod in disseminierten tumorzellen

Translated title of the contribution: Cell growth and cell death in disseminated tumor cells

G. Méhes, Ruth Ladenstein, H. Gadner, P. F. Ambros

Research output: Contribution to journalArticle

Abstract

The occurrance of occult metastases of solid tumors at initial diagnosis or during follow-up is of crucial therapeutical importance. The sensitive detection of such cells in hematological samples depends on tissue specific cellular markers. The demonstration of minimally disseminated tumor cells at a given timepoint is, however, only a snapshot, which does not give any information about the potential and dynamics of the cells in question. Functional differences may fundamentally influence the impact of a positive finding. The analysis of cell proliferation and cell death (apoptosis) in disseminated tumor cells, for instance, defines, whether the dissemination process is progressive or regressive. With a newly developed automatic image analysis station the investigation of functional parameters in isolated cells from clinical samples became possible. The studies presented here demonstrate, that such techniques allow an improved identification of isolated tumor cells with clinical importance.

Original languageGerman
Pages (from-to)62-64
Number of pages3
JournalActa Medica Austriaca
Volume29
Issue numberSUPPL. 59
Publication statusPublished - 2002

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Cell Death
Growth
Neoplasms
Cell Proliferation
Apoptosis
Neoplasm Metastasis

Keywords

  • Automatic immunological plus FISH
  • Disseminated tumor cells
  • Fluorescence in situ hybridiation
  • Immunology
  • Minimal residual disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Méhes, G., Ladenstein, R., Gadner, H., & Ambros, P. F. (2002). Zellproliferation und zelltod in disseminierten tumorzellen. Acta Medica Austriaca, 29(SUPPL. 59), 62-64.

Zellproliferation und zelltod in disseminierten tumorzellen. / Méhes, G.; Ladenstein, Ruth; Gadner, H.; Ambros, P. F.

In: Acta Medica Austriaca, Vol. 29, No. SUPPL. 59, 2002, p. 62-64.

Research output: Contribution to journalArticle

Méhes, G, Ladenstein, R, Gadner, H & Ambros, PF 2002, 'Zellproliferation und zelltod in disseminierten tumorzellen', Acta Medica Austriaca, vol. 29, no. SUPPL. 59, pp. 62-64.
Méhes G, Ladenstein R, Gadner H, Ambros PF. Zellproliferation und zelltod in disseminierten tumorzellen. Acta Medica Austriaca. 2002;29(SUPPL. 59):62-64.
Méhes, G. ; Ladenstein, Ruth ; Gadner, H. ; Ambros, P. F. / Zellproliferation und zelltod in disseminierten tumorzellen. In: Acta Medica Austriaca. 2002 ; Vol. 29, No. SUPPL. 59. pp. 62-64.
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