Cell cycle control of activated, synchronized murine B lymphocytes-roles of macrophages and complement C3

Fritz Melchers, A. Erdei, Catherine Corbel, Maria Leptin, Thomas Schulz, Manfred P. Dierich

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Three restriction points control the cell cycle of activated murine B lymphocytes in a synergistic way. The first is controlled by the occupancy of surface immunoglobulin either by antigen- or by immunoglobulin-specific antibodies. The second is controlled by the complement C3d receptor CR2 which can be occupied by cross-linked C3b or C3d to stimulate the entry into S phase, or by soluble C3d or a C3 α-chain peptide, binding to the CR2 receptor, which inhibit the entry into S phase. Macrophages produce so-called α factors which also control the B-cell cycle at the same point. Thus, it is suspected that macrophages produce components of the early pathway of complement activation which finally lead to cross-linking of CR2 receptors on B cells. The third restriction point is controlled by unknown receptors that recognize so-called β factors produced by helper T lymphocytes.

Original languageEnglish
Pages (from-to)1173-1176
Number of pages4
JournalMolecular Immunology
Volume23
Issue number11
DOIs
Publication statusPublished - 1986

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Complement 3d Receptors
Complement C3
Cell Cycle Checkpoints
B-Lymphocytes
Macrophages
S Phase
Complement C3d
Complement Receptors
B-Cell Antigen Receptors
Complement Activation
Helper-Inducer T-Lymphocytes
Immunoglobulins
Antigens
Peptides
Antibodies

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Cell cycle control of activated, synchronized murine B lymphocytes-roles of macrophages and complement C3. / Melchers, Fritz; Erdei, A.; Corbel, Catherine; Leptin, Maria; Schulz, Thomas; Dierich, Manfred P.

In: Molecular Immunology, Vol. 23, No. 11, 1986, p. 1173-1176.

Research output: Contribution to journalArticle

Melchers, Fritz ; Erdei, A. ; Corbel, Catherine ; Leptin, Maria ; Schulz, Thomas ; Dierich, Manfred P. / Cell cycle control of activated, synchronized murine B lymphocytes-roles of macrophages and complement C3. In: Molecular Immunology. 1986 ; Vol. 23, No. 11. pp. 1173-1176.
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