Cell cycle control by the target of rapamycin signalling pathway in plants

Zaki Ahmad, Z. Magyar, László Bögre, Csaba Papdi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cells need to ensure a sufficient nutrient and energy supply before committing to proliferate. In response to positive mitogenic signals, such as light, sugar availability, and hormones, the target of rapamycin (TOR) signalling pathway promotes cell growth that connects to the entry and passage through the cell division cycle via multiple signalling mechanisms. Here, we summarize current understanding of cell cycle regulation by the RBR-E2F regulatory hub and the DREAM-like complexes, and highlight possible functional relationships between these regulators and TOR signalling. A genetic screen recently uncovered a downstream signalling component to TOR that regulates cell proliferation, YAK1, a member of the dual specificity tyrosine phosphorylation-regulated kinase (DYRK) family. YAK1 activates the plant-specific SIAMESE-RELATED (SMR) cyclin-dependent kinase inhibitors and therefore could be important to regulate both the CDKA-RBR-E2F pathway to control the G1/S transition and the mitotic CDKB1;1 to control the G2/M transition. TOR, as a master regulator of both protein synthesis-driven cell growth and cell proliferation is also central for cell size homeostasis. We conclude the review by briefly highlighting the potential applications of combining TOR and cell cycle knowledge in the context of ensuring future food security.

Original languageEnglish
Pages (from-to)2275-2284
Number of pages10
JournalJournal of experimental botany
Volume70
Issue number8
DOIs
Publication statusPublished - Apr 15 2019

Fingerprint

Sirolimus
Cell Cycle Checkpoints
cell growth
cell cycle
cell proliferation
cyclin-dependent kinase
Cell Cycle
food security
tyrosine
cell division
homeostasis
phosphorylation
phosphotransferases (kinases)
protein synthesis
hormones
cells
sugars
Cell Proliferation
energy
nutrients

Keywords

  • Cell cycle
  • DREAM
  • E2F
  • protein translation control
  • retinoblastoma
  • TOR

ASJC Scopus subject areas

  • Physiology
  • Plant Science

Cite this

Cell cycle control by the target of rapamycin signalling pathway in plants. / Ahmad, Zaki; Magyar, Z.; Bögre, László; Papdi, Csaba.

In: Journal of experimental botany, Vol. 70, No. 8, 15.04.2019, p. 2275-2284.

Research output: Contribution to journalArticle

Ahmad, Zaki ; Magyar, Z. ; Bögre, László ; Papdi, Csaba. / Cell cycle control by the target of rapamycin signalling pathway in plants. In: Journal of experimental botany. 2019 ; Vol. 70, No. 8. pp. 2275-2284.
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