Celiac disease and microscopic colitis: A report of 4 cases

Z. Barta, Eva Zold, Arpad Nagy, M. Zeher, I. Csípő

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ages. However, it can be associated also to other immunopathological disorders, and may be associated with abnormal histology in segments of the gut other than the small bowel including colonic inflammation. While guidelines for endoscopic investigation of the jejunum are well defined, no indication is defined for colonic investigation. We describe four cases of concurrent CD and microscopic colitis (MC) diagnosed at our department over a 10-year period and analyzed the main features and outcomes of CD in this setting. The symptoms of these patients were improved initially by a gluten-free diet before the onset of MC symptoms. Two of the patients were siblings and had an atypical form of CD. The other two patients with CD and MC also presented with fibrosing alveolitis and were anti-Saccharomyces cerevisiae antibody positive. The co-existence of immune-mediated small bowel and colonic inflammatory and pulmonary diseases are not well-known, and no systematic approach has been used to identify the lifelong patterns of these immune-based diseases. Patients can develop, or present with CD at any stage in life, which can co-exist with other gastrointestinal diseases of (auto-) immune origin. In addition, the familial co-existence and prevalence of MC in patients with a prior diagnosis of CD are unclear. Clinicians managing celiac disease should be aware of these associations and understand when to consider colon investigation.

Original languageEnglish
Pages (from-to)2150-2154
Number of pages5
JournalWorld Journal of Gastroenterology
Volume17
Issue number16
DOIs
Publication statusPublished - Apr 28 2011

Fingerprint

Microscopic Colitis
Celiac Disease
Colonic Diseases
Gluten-Free Diet
Pulmonary Fibrosis
Gastrointestinal Diseases
Immune System Diseases
Jejunum
Lung Diseases
Small Intestine
Saccharomyces cerevisiae
Siblings
Histology
Colon
Guidelines
Inflammation

Keywords

  • Anti-saccharomyces cerevi-siae antibody
  • Celiac disease
  • Collagen colitis
  • Fibrosing alveolitis
  • Lymphocytic colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Celiac disease and microscopic colitis : A report of 4 cases. / Barta, Z.; Zold, Eva; Nagy, Arpad; Zeher, M.; Csípő, I.

In: World Journal of Gastroenterology, Vol. 17, No. 16, 28.04.2011, p. 2150-2154.

Research output: Contribution to journalArticle

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