CECOG experts' recommendations on the use of denosumab in the prevention of skeletal-related events in bone metastases of lung cancer

Wolfgang Hilbe, Ufuk Abacioglu, Daniel M. Aebersold, Mounir Bachouchi, Thomas Brodowicz, Rabab Gaafar, Gerold Holzer, Andrea Mohn-Staudner, Dimitar Kalev, Ewa Kalinka-Warzocha, Viljem Kovac, Marco Siano, Fulden Yumuk, Lilla Tamasi

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Abstract

Purpose: Skeletal-related events represent a substantial burden for patients with advanced cancer. Randomized, controlled studies suggested superiority of denosumab over zoledronic acid in the prevention of skeletal-related events in metastatic cancer patients, with a favorable safety profile. Experts gathered at the 2012 Skeletal Care Academy in Istanbul to bring forward practical recommendations, based on current evidence, for the use of denosumab in patients with bone metastases of lung cancer. Recommendations: Based on current evidence, use of denosumab in lung cancer patients with confirmed bone metastases is recommended. It is important to note that clinical judgment should take into consideration the patient's general performance status, overall prognosis, and live expectancy. Currently, the adverse event profile reported for denosumab includes hypocalcemia and infrequent occurrence of osteonecrosis of the jaw. Therefore, routine calcium and vitamin D supplementation, along with dental examination prior to denosumab initiation are recommended. There is no evidence for renal function impairment due to denosumab administration. At present, there is no rationale to discourage concomitant use of denosumab and surgery or radiotherapy.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalMemo - Magazine of European Medical Oncology
Volume6
Issue number2
DOIs
Publication statusPublished - Jun 1 2013

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Keywords

  • Bone metastases
  • Denosumab
  • Lung cancer
  • RANK ligand
  • Skeletal-related events

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Hilbe, W., Abacioglu, U., Aebersold, D. M., Bachouchi, M., Brodowicz, T., Gaafar, R., Holzer, G., Mohn-Staudner, A., Kalev, D., Kalinka-Warzocha, E., Kovac, V., Siano, M., Yumuk, F., & Tamasi, L. (2013). CECOG experts' recommendations on the use of denosumab in the prevention of skeletal-related events in bone metastases of lung cancer. Memo - Magazine of European Medical Oncology, 6(2), 75-82. https://doi.org/10.1007/s12254-013-0088-6