CE enantioseparation of betti bases with cyclodextrins and crown ether as chiral selectors

István Ilisz, Róbert Iványi, Zoltán Pataj, József Kupai, Péter Huszthy, István Szatmári, Ferenc Fülöp, Antal Péter

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Direct capillary zone electrophoretic methods were developed for the separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol and 2-(a-aminoarylmethyl)-1-naphthol analogues. The effects of selector and buffer concentrations, electrolyte pH and applied voltage on the separation efficiency were studied. Variation of the electrophoretic conditions with the application of negative polarity, hydrodynamic injection, an unmodified silica capillary, different buffers and sulfated cyclodextrins and (S,S)-dimethylpyridino-18- crown-6 ether as chiral selectors led to the baseline resolution of all the compounds investigated.

Original languageEnglish
Pages (from-to)S115-S119
JournalChromatographia
Volume71
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jun 1 2010

Keywords

  • 1-(α-Aminoarylmethyl)-2-naphthol and 2-(α-aminoarylmethyl)-1-naphthol analogues
  • Capillary electrophoresis
  • Chiral crown ether
  • Cyclodextrin sulfates
  • Enantiomer separation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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