CD84 cell surface signaling molecule: An emerging biomarker and target for cancer and autoimmune disorders

Marta Cuenca, Jordi Sintes, A. Lányi, Pablo Engel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

CD84 (SLAMF5) is a member of the SLAM family of cell-surface immunoreceptors. Broadly expressed on most immune cell subsets, CD84 functions as a homophilic adhesion molecule, whose signaling can activate or inhibit leukocyte function depending on the cell type and its stage of activation or differentiation. CD84-mediated signaling regulates diverse immunological processes, including T cell cytokine secretion, natural killer cell cytotoxicity, monocyte activation, autophagy, cognate T:B interactions, and B cell tolerance at the germinal center checkpoint. Recently, alterations in CD84 have been related to autoimmune and lymphoproliferative disorders. Specific allelic variations in CD84 are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In chronic lymphocytic leukemia, CD84 mediates intrinsic and stroma-induced survival of malignant cells. In this review, we describe our current understanding of the structure and function of CD84 and its potential role as a therapeutic target and biomarker in inflammatory autoimmune disorders and cancer.

Original languageEnglish
JournalClinical Immunology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Tumor Biomarkers
Germinal Center
Lymphoproliferative Disorders
Autophagy
B-Cell Chronic Lymphocytic Leukemia
Natural Killer Cells
Systemic Lupus Erythematosus
Autoimmune Diseases
Monocytes
Rheumatoid Arthritis
Cell Survival
Leukocytes
B-Lymphocytes
Biomarkers
Cytokines
T-Lymphocytes
Neoplasms
Therapeutics

Keywords

  • Autoimmune disorders
  • Autophagy
  • CD84
  • Chronic lymphocytic leukemia (CLL)
  • Disease biomarkers
  • Germinal center (GC)
  • SLAM family receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

CD84 cell surface signaling molecule : An emerging biomarker and target for cancer and autoimmune disorders. / Cuenca, Marta; Sintes, Jordi; Lányi, A.; Engel, Pablo.

In: Clinical Immunology, 01.01.2018.

Research output: Contribution to journalArticle

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