CD-15 antigen detected by the VIM-D5 monoclonal antibody for prediction of ability to achieve complete remission in acute nonlymphocytic leukemia1

J. Hołowiecki, D. Lutz, S. Krzemień, B. Stella-Hołowiecka, F. Graf, G. Kelenyi, V. Schranz, V. Callea, M. Brugiatelli, A. Neri, T. Magyarlaki, R. Ihle, K. Jagoda, E. Rudzka

Research output: Contribution to journalArticle

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Abstract

The prognostic value of cell differentiation antigens detected with the monoclonal antibodies of VI series was studied in 242 cases of acute nonlymphoblastic leukemia (ANLL) treated in 7 cooperating centers. A significantly higher complete remission rate was observed in patients with a higher expression of CD-15 antigen detected by VIM-D5 antibody than in those with lower values. These significant differences were proved when comparing subgroups with VIM-D5 positivity of blastic cells < 15 and > 15% (p < 0.01) as well as in the subgroups with values < 50% (median value) and ≥ 50% (p < 0.02). Our studies suggest the VIM-D5 positivity of ANLL cells to be favourable prognostic factor predicting the ability to achieve complete remission. Further studies are needed to establish whether the expression of the VIM-D5-defined antigen may serve as a prognostic factor related to survival.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalActa Haematologica
Volume76
Issue number1
DOIs
Publication statusPublished - 1986

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CD Antigens
Acute Myeloid Leukemia
Monoclonal Antibodies
Differentiation Antigens
Cell Differentiation
Antigens
Survival
Antibodies

Keywords

  • Differentiation antigens
  • Leukemia, acute, nonlymphocytic
  • Monoclonal antibodies
  • Prognostic factors

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology

Cite this

CD-15 antigen detected by the VIM-D5 monoclonal antibody for prediction of ability to achieve complete remission in acute nonlymphocytic leukemia1. / Hołowiecki, J.; Lutz, D.; Krzemień, S.; Stella-Hołowiecka, B.; Graf, F.; Kelenyi, G.; Schranz, V.; Callea, V.; Brugiatelli, M.; Neri, A.; Magyarlaki, T.; Ihle, R.; Jagoda, K.; Rudzka, E.

In: Acta Haematologica, Vol. 76, No. 1, 1986, p. 16-19.

Research output: Contribution to journalArticle

Hołowiecki, J, Lutz, D, Krzemień, S, Stella-Hołowiecka, B, Graf, F, Kelenyi, G, Schranz, V, Callea, V, Brugiatelli, M, Neri, A, Magyarlaki, T, Ihle, R, Jagoda, K & Rudzka, E 1986, 'CD-15 antigen detected by the VIM-D5 monoclonal antibody for prediction of ability to achieve complete remission in acute nonlymphocytic leukemia1', Acta Haematologica, vol. 76, no. 1, pp. 16-19. https://doi.org/10.1159/000206011
Hołowiecki, J. ; Lutz, D. ; Krzemień, S. ; Stella-Hołowiecka, B. ; Graf, F. ; Kelenyi, G. ; Schranz, V. ; Callea, V. ; Brugiatelli, M. ; Neri, A. ; Magyarlaki, T. ; Ihle, R. ; Jagoda, K. ; Rudzka, E. / CD-15 antigen detected by the VIM-D5 monoclonal antibody for prediction of ability to achieve complete remission in acute nonlymphocytic leukemia1. In: Acta Haematologica. 1986 ; Vol. 76, No. 1. pp. 16-19.
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