CCL21 and IP-10 as blood biomarkers for pulmonary involvement in systemic lupus erythematosus patients

B. Odler, A. Bikov, J. Streizig, C. Balogh, E. Kiss, K. Vincze, I. Barta, I. Horváth, V. Müller

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Biomarkers for pulmonary manifestations in systemic lupus erythematosus (SLE) are missing. Plasma samples of nine SLE patients with known pulmonary involvement (SLEpulm) and nine SLE patients without pulmonary involvement (SLE) were tested by multiplex microarray analysis for various cyto- and chemokines. Significantly decreased lung function paramters for forced vital capacity (FVC), total lung capacity (TLC), diffusion capacity for carbon monoxide (DLCO) and diffusion of CO corrected on lung volume (KLCO) were observed in SLEpulm as compared to SLE patients. CC chemokine ligand 21 (CCL21) and interferon gamma-induced protein 10 (IP-10) levels were significantly higher in SLEpulm, than in patients without pulmonary manifestations. CCL21 correlated negatively with DLCO (r = -'0.73; p < 0.01) and KLCO (r = -'0.62; p < 0.01), while IP-10 with FVC and forced expiratory volume one second. Receiver Operating Characteristics (ROC) analysis confirmed high sensitivity and specificity for the separation of SLE patients with and without pulmonary involvement for the chemokines CCL21 (Area Under Curve (AUC): 0.85; sensitivity%: 88.90; specificity%: 75.00; p < 0.01) and IP-10 (AUC: 0.82; sensitivity%: 66.67, specificity%: 100; p < 0.01). Pleuropulmonary manifestations in SLE patients associated with lung functional and DLCO/KLCO changes and were associated with significant increase in CCL21 and IP-10. These chemokines might serve as potential biomarkers of lung involvement in SLE patients.

Original languageEnglish
Pages (from-to)572-579
Number of pages8
JournalLupus
Volume26
Issue number6
DOIs
Publication statusPublished - May 1 2017

Fingerprint

CC Chemokines
Systemic Lupus Erythematosus
Biomarkers
Ligands
Lung
Proteins
Chemokines
Vital Capacity
Carbon Monoxide
Sensitivity and Specificity
Area Under Curve
Total Lung Capacity
Forced Expiratory Volume
Microarray Analysis
ROC Curve
Interferon-gamma
Cytokines

Keywords

  • CCL21
  • diffusion capacity
  • immunoassay
  • IP-10
  • lung function
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

CCL21 and IP-10 as blood biomarkers for pulmonary involvement in systemic lupus erythematosus patients. / Odler, B.; Bikov, A.; Streizig, J.; Balogh, C.; Kiss, E.; Vincze, K.; Barta, I.; Horváth, I.; Müller, V.

In: Lupus, Vol. 26, No. 6, 01.05.2017, p. 572-579.

Research output: Contribution to journalArticle

Odler, B. ; Bikov, A. ; Streizig, J. ; Balogh, C. ; Kiss, E. ; Vincze, K. ; Barta, I. ; Horváth, I. ; Müller, V. / CCL21 and IP-10 as blood biomarkers for pulmonary involvement in systemic lupus erythematosus patients. In: Lupus. 2017 ; Vol. 26, No. 6. pp. 572-579.
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AU - Kiss, E.

AU - Vincze, K.

AU - Barta, I.

AU - Horváth, I.

AU - Müller, V.

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AB - Biomarkers for pulmonary manifestations in systemic lupus erythematosus (SLE) are missing. Plasma samples of nine SLE patients with known pulmonary involvement (SLEpulm) and nine SLE patients without pulmonary involvement (SLE) were tested by multiplex microarray analysis for various cyto- and chemokines. Significantly decreased lung function paramters for forced vital capacity (FVC), total lung capacity (TLC), diffusion capacity for carbon monoxide (DLCO) and diffusion of CO corrected on lung volume (KLCO) were observed in SLEpulm as compared to SLE patients. CC chemokine ligand 21 (CCL21) and interferon gamma-induced protein 10 (IP-10) levels were significantly higher in SLEpulm, than in patients without pulmonary manifestations. CCL21 correlated negatively with DLCO (r = -'0.73; p < 0.01) and KLCO (r = -'0.62; p < 0.01), while IP-10 with FVC and forced expiratory volume one second. Receiver Operating Characteristics (ROC) analysis confirmed high sensitivity and specificity for the separation of SLE patients with and without pulmonary involvement for the chemokines CCL21 (Area Under Curve (AUC): 0.85; sensitivity%: 88.90; specificity%: 75.00; p < 0.01) and IP-10 (AUC: 0.82; sensitivity%: 66.67, specificity%: 100; p < 0.01). Pleuropulmonary manifestations in SLE patients associated with lung functional and DLCO/KLCO changes and were associated with significant increase in CCL21 and IP-10. These chemokines might serve as potential biomarkers of lung involvement in SLE patients.

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