CCL genes in multiple sclerosis and systemic lupus erythematosus

Tamara Vyshkina, Andrew Sylvester, Saud Sadiq, Eduardo Bonilla, Andras Perl, B. Kálmán

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This follow up study aims to refine the roles of previously suggested candidate genes (CC chemokine ligands or CCLs) in multiple sclerosis (MS), and to test these markers in another autoimmune disorder, systemic lupus erythematosus (SLE). After stringent correction for multiple testing, we reject the importance of previously suggested borderline associations with CCLs in MS. A new finding is the differential distribution of CCL8 marker alleles and a haplotype in extreme severity subgroups of MS. In SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalJournal of Neuroimmunology
Volume200
Issue number1-2
DOIs
Publication statusPublished - Aug 30 2008

Fingerprint

Systemic Lupus Erythematosus
Haplotypes
Multiple Sclerosis
Genes
CC Chemokines
Alleles
Ligands

Keywords

  • Candidate genes
  • CC chemokine ligands
  • Multiple sclerosis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

CCL genes in multiple sclerosis and systemic lupus erythematosus. / Vyshkina, Tamara; Sylvester, Andrew; Sadiq, Saud; Bonilla, Eduardo; Perl, Andras; Kálmán, B.

In: Journal of Neuroimmunology, Vol. 200, No. 1-2, 30.08.2008, p. 145-152.

Research output: Contribution to journalArticle

Vyshkina, T, Sylvester, A, Sadiq, S, Bonilla, E, Perl, A & Kálmán, B 2008, 'CCL genes in multiple sclerosis and systemic lupus erythematosus', Journal of Neuroimmunology, vol. 200, no. 1-2, pp. 145-152. https://doi.org/10.1016/j.jneuroim.2008.05.016
Vyshkina, Tamara ; Sylvester, Andrew ; Sadiq, Saud ; Bonilla, Eduardo ; Perl, Andras ; Kálmán, B. / CCL genes in multiple sclerosis and systemic lupus erythematosus. In: Journal of Neuroimmunology. 2008 ; Vol. 200, No. 1-2. pp. 145-152.
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