CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure

Andor Pivarcsi, Michael Gombert, Marie Caroline Dieu-Nosjean, Antti Lauerma, Robert Kubitza, Stephan Meller, Juliane Rieker, Anja Muller, Ludivine Da Cunha, Anna Haahtela, Eniko Sonkoly, Wolf Herman Fridman, Harri Alenius, L. Kemény, Thomas Ruzicka, Albert Zlotnik, Bernhard Homey

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with an atopic dermatitis phenotype when compared with other chronic inflammatory skin diseases. DCs either dispersed within the dermis or clustering at sites showing perivascular infiltrates are abundant sources of CCL18. In vitro, microbial products including LPS, peptidoglycan, and mannan, as well as the T cell-derived activation signal CD40L, induced CCL18 in monocytes. In contrast to monocytes, monocyte-derived, interstitial-type, and Langerhans-type DCs showed a constitutive and abundant expression of CCL18. In comparison to Langerhans cells, interstitial-type DCs produced higher constitutive levels of CCL18. In vivo, topical exposure to the relevant allergen or the superantigen staphytococcal enterotoxin B, resulted in a significant induction of CCL18 in atopic dermatitis patients. Furthermore, in nonatopic NiSO4-sensitized individuals, only relevant allergen but not irritant exposure resulted in the induction of CCL18. Taken together, findings of the present study demonstrate that CCL18 is associated with an atopy/allergy skin phenotype, and is expressed at the interface between the environment and the host by cells constantly screening foreign Ags. Its regulation by allergen exposure and microbial products suggests an important role for CCL18 in the initiation and amplification of atopic skin inflammation.

Original languageEnglish
Pages (from-to)5810-5817
Number of pages8
JournalJournal of Immunology
Volume173
Issue number9
Publication statusPublished - Nov 1 2004

Fingerprint

CC Chemokines
Atopic Dermatitis
Chemokines
Allergens
Dendritic Cells
Ligands
Monocytes
Superantigens
Skin Diseases
Skin
Inflammation
T-Lymphocytes
Phenotype
Mannans
CD40 Ligand
Langerhans Cells
Peptidoglycan
Irritants
Enterotoxins
Dermis

ASJC Scopus subject areas

  • Immunology

Cite this

Pivarcsi, A., Gombert, M., Dieu-Nosjean, M. C., Lauerma, A., Kubitza, R., Meller, S., ... Homey, B. (2004). CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. Journal of Immunology, 173(9), 5810-5817.

CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. / Pivarcsi, Andor; Gombert, Michael; Dieu-Nosjean, Marie Caroline; Lauerma, Antti; Kubitza, Robert; Meller, Stephan; Rieker, Juliane; Muller, Anja; Da Cunha, Ludivine; Haahtela, Anna; Sonkoly, Eniko; Fridman, Wolf Herman; Alenius, Harri; Kemény, L.; Ruzicka, Thomas; Zlotnik, Albert; Homey, Bernhard.

In: Journal of Immunology, Vol. 173, No. 9, 01.11.2004, p. 5810-5817.

Research output: Contribution to journalArticle

Pivarcsi, A, Gombert, M, Dieu-Nosjean, MC, Lauerma, A, Kubitza, R, Meller, S, Rieker, J, Muller, A, Da Cunha, L, Haahtela, A, Sonkoly, E, Fridman, WH, Alenius, H, Kemény, L, Ruzicka, T, Zlotnik, A & Homey, B 2004, 'CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure', Journal of Immunology, vol. 173, no. 9, pp. 5810-5817.
Pivarcsi, Andor ; Gombert, Michael ; Dieu-Nosjean, Marie Caroline ; Lauerma, Antti ; Kubitza, Robert ; Meller, Stephan ; Rieker, Juliane ; Muller, Anja ; Da Cunha, Ludivine ; Haahtela, Anna ; Sonkoly, Eniko ; Fridman, Wolf Herman ; Alenius, Harri ; Kemény, L. ; Ruzicka, Thomas ; Zlotnik, Albert ; Homey, Bernhard. / CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. In: Journal of Immunology. 2004 ; Vol. 173, No. 9. pp. 5810-5817.
@article{1fbb97bae26445dd9c11318f0e5193bc,
title = "CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure",
abstract = "Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with an atopic dermatitis phenotype when compared with other chronic inflammatory skin diseases. DCs either dispersed within the dermis or clustering at sites showing perivascular infiltrates are abundant sources of CCL18. In vitro, microbial products including LPS, peptidoglycan, and mannan, as well as the T cell-derived activation signal CD40L, induced CCL18 in monocytes. In contrast to monocytes, monocyte-derived, interstitial-type, and Langerhans-type DCs showed a constitutive and abundant expression of CCL18. In comparison to Langerhans cells, interstitial-type DCs produced higher constitutive levels of CCL18. In vivo, topical exposure to the relevant allergen or the superantigen staphytococcal enterotoxin B, resulted in a significant induction of CCL18 in atopic dermatitis patients. Furthermore, in nonatopic NiSO4-sensitized individuals, only relevant allergen but not irritant exposure resulted in the induction of CCL18. Taken together, findings of the present study demonstrate that CCL18 is associated with an atopy/allergy skin phenotype, and is expressed at the interface between the environment and the host by cells constantly screening foreign Ags. Its regulation by allergen exposure and microbial products suggests an important role for CCL18 in the initiation and amplification of atopic skin inflammation.",
author = "Andor Pivarcsi and Michael Gombert and Dieu-Nosjean, {Marie Caroline} and Antti Lauerma and Robert Kubitza and Stephan Meller and Juliane Rieker and Anja Muller and {Da Cunha}, Ludivine and Anna Haahtela and Eniko Sonkoly and Fridman, {Wolf Herman} and Harri Alenius and L. Kem{\'e}ny and Thomas Ruzicka and Albert Zlotnik and Bernhard Homey",
year = "2004",
month = "11",
day = "1",
language = "English",
volume = "173",
pages = "5810--5817",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "9",

}

TY - JOUR

T1 - CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure

AU - Pivarcsi, Andor

AU - Gombert, Michael

AU - Dieu-Nosjean, Marie Caroline

AU - Lauerma, Antti

AU - Kubitza, Robert

AU - Meller, Stephan

AU - Rieker, Juliane

AU - Muller, Anja

AU - Da Cunha, Ludivine

AU - Haahtela, Anna

AU - Sonkoly, Eniko

AU - Fridman, Wolf Herman

AU - Alenius, Harri

AU - Kemény, L.

AU - Ruzicka, Thomas

AU - Zlotnik, Albert

AU - Homey, Bernhard

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with an atopic dermatitis phenotype when compared with other chronic inflammatory skin diseases. DCs either dispersed within the dermis or clustering at sites showing perivascular infiltrates are abundant sources of CCL18. In vitro, microbial products including LPS, peptidoglycan, and mannan, as well as the T cell-derived activation signal CD40L, induced CCL18 in monocytes. In contrast to monocytes, monocyte-derived, interstitial-type, and Langerhans-type DCs showed a constitutive and abundant expression of CCL18. In comparison to Langerhans cells, interstitial-type DCs produced higher constitutive levels of CCL18. In vivo, topical exposure to the relevant allergen or the superantigen staphytococcal enterotoxin B, resulted in a significant induction of CCL18 in atopic dermatitis patients. Furthermore, in nonatopic NiSO4-sensitized individuals, only relevant allergen but not irritant exposure resulted in the induction of CCL18. Taken together, findings of the present study demonstrate that CCL18 is associated with an atopy/allergy skin phenotype, and is expressed at the interface between the environment and the host by cells constantly screening foreign Ags. Its regulation by allergen exposure and microbial products suggests an important role for CCL18 in the initiation and amplification of atopic skin inflammation.

AB - Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with an atopic dermatitis phenotype when compared with other chronic inflammatory skin diseases. DCs either dispersed within the dermis or clustering at sites showing perivascular infiltrates are abundant sources of CCL18. In vitro, microbial products including LPS, peptidoglycan, and mannan, as well as the T cell-derived activation signal CD40L, induced CCL18 in monocytes. In contrast to monocytes, monocyte-derived, interstitial-type, and Langerhans-type DCs showed a constitutive and abundant expression of CCL18. In comparison to Langerhans cells, interstitial-type DCs produced higher constitutive levels of CCL18. In vivo, topical exposure to the relevant allergen or the superantigen staphytococcal enterotoxin B, resulted in a significant induction of CCL18 in atopic dermatitis patients. Furthermore, in nonatopic NiSO4-sensitized individuals, only relevant allergen but not irritant exposure resulted in the induction of CCL18. Taken together, findings of the present study demonstrate that CCL18 is associated with an atopy/allergy skin phenotype, and is expressed at the interface between the environment and the host by cells constantly screening foreign Ags. Its regulation by allergen exposure and microbial products suggests an important role for CCL18 in the initiation and amplification of atopic skin inflammation.

UR - http://www.scopus.com/inward/record.url?scp=6344241439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6344241439&partnerID=8YFLogxK

M3 - Article

VL - 173

SP - 5810

EP - 5817

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 9

ER -