Caveolae and the regulation of endocytosis

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Citations (Scopus)

Abstract

Although clathrin-mediated endocytosis constitutes the main pathway for internalization of extracellular ligands and plasma membrane components it has generally been accepted that other uptake mechanisms-caveolae-mediated and noncaveolar raft-dependent endocytosis-also exist. During the last 20 years many papers have been published about caveolar endocytosis. These studies have fundamentally changed our view about the endocytotic role of caveolae. Views that caveolae are permanently static structures 1 have been extensively considered and rejected. Although the initial steps leading to the pinching off of caveolae from the plasma membrane have been studied in details, there are still contradictory data about the intracellular trafficking of caveolae. It is still not entirely clear whether caveolar endocytosis represents an uptake pathway with distinct cellular compartments to avoid lysosomal degradation or ligands taken up by caveolae can also be targeted to late endosomes/lysosomes. In this chapter, we summarize the data available about caveolar endocytosis focusing on the intracellular route of caveolae and we provide data supporting that caveolar endocytosis can join the classical endocytotic pathway.

Original languageEnglish
Title of host publicationCaveolins and Caveolae
Subtitle of host publicationRoles in Signaling and Disease Mechanisms
Pages14-28
Number of pages15
DOIs
Publication statusPublished - Apr 20 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume729
ISSN (Print)0065-2598

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kiss, A. L. (2012). Caveolae and the regulation of endocytosis. In Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms (pp. 14-28). (Advances in Experimental Medicine and Biology; Vol. 729). https://doi.org/10.1007/978-1-4614-1222-9_2