Causal study of isolated ulnar-fibular deficiency in Hungary, 1975-1984

E. Czeizel, M. Vitez, I. Kodaj, W. Lenz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A population-based and validated data set of 114 cases with isolated ulnar-fibular deficiency was evaluated in Hungary, 1975-1984. Ulnar-fibular type had the third most common birth prevalence (0.07 per 1000) among isolated congenital limb deficiency types. This type is relatively rarely associated with nonlimb defects, a single limb is affected in two-thirds of cases, nearly all other cases had femur-fibula-ulna (FFU) dysostosis. Upper and lower limbs, right and left sides, are equally affected, however, there is an obvious male excess (71%). Case-control analysis indicated a lower birth weight due to intrauterine growth retardation, higher birth order, lower socioeconomic status of parents, and a more frequent reported subfertility. The family study identified one familial cluster (one siboccurrence) among 331 first-degree relatives.

Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalAmerican Journal of Medical Genetics
Volume46
Issue number4
Publication statusPublished - 1993

Fingerprint

Hungary
Extremities
Dysostoses
Ulna
Fibula
Birth Order
Fetal Growth Retardation
Birth Weight
Social Class
Femur
Infertility
Lower Extremity
Parents
Parturition
Population
Datasets

Keywords

  • congenital limb deficiency
  • femur-fibula-ulna dysostosis
  • subfertility
  • ulnar-fibular type

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Causal study of isolated ulnar-fibular deficiency in Hungary, 1975-1984. / Czeizel, E.; Vitez, M.; Kodaj, I.; Lenz, W.

In: American Journal of Medical Genetics, Vol. 46, No. 4, 1993, p. 427-433.

Research output: Contribution to journalArticle

Czeizel, E. ; Vitez, M. ; Kodaj, I. ; Lenz, W. / Causal study of isolated ulnar-fibular deficiency in Hungary, 1975-1984. In: American Journal of Medical Genetics. 1993 ; Vol. 46, No. 4. pp. 427-433.
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