Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

Daniel Hillier, Michele Fiscella, Antonia Drinnenberg, Stuart Trenholm, Santiago B. Rompani, Zoltan Raics, Gergely Katona, Josephine Juettner, Andreas Hierlemann, Balazs Rozsa, Botond Roska

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38 Citations (Scopus)

Abstract

How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined this question in the context of visual-motion processing in the retina and primary visual cortex (V1) of mice. We disrupted retinal direction selectivity, either exclusively along the horizontal axis using FRMD7 mutants or along all directions by ablating starburst amacrine cells, and monitored neuronal activity in layer 2/3 of V1 during stimulation with visual motion. In control mice, we found an over-representation of cortical cells preferring posterior visual motion, the dominant motion direction an animal experiences when it moves forward. In mice with disrupted retinal direction selectivity, the over-representation of posterior-motion-preferring cortical cells disappeared, and their responses at higher stimulus speeds were reduced. This work reveals the existence of two functionally distinct, sensory-periphery-dependent and -independent computations of visual motion in the cortex.

Original languageEnglish
Pages (from-to)960-968
Number of pages9
JournalNature Neuroscience
Volume20
Issue number7
DOIs
Publication statusPublished - Jun 27 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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    Hillier, D., Fiscella, M., Drinnenberg, A., Trenholm, S., Rompani, S. B., Raics, Z., Katona, G., Juettner, J., Hierlemann, A., Rozsa, B., & Roska, B. (2017). Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex. Nature Neuroscience, 20(7), 960-968. https://doi.org/10.1038/nn.4566