Catheter-directed thrombolysis in inflammatory bowel diseases: Report of a case

Péter Ilonczai, Judit Tóth, L. Tóth, I. Altorjay, Z. Boda, K. Palatka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. The TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. The application of anticoagulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. The control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. This case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.

Original languageEnglish
Pages (from-to)4791-4793
Number of pages3
JournalWorld Journal of Gastroenterology
Volume18
Issue number34
DOIs
Publication statusPublished - 2012

Fingerprint

Thromboembolism
Inflammatory Bowel Diseases
Radial Artery
Catheters
Angiography
Hemorrhage
Brachial Artery
Thrombolytic Therapy
Tissue Plasminogen Activator
Upper Extremity
Crohn Disease
Anticoagulants
Endoscopy
Blood Vessels
Pulse
Anemia
Colon
Thrombosis
Hand
Inflammation

Keywords

  • Catheter-directed thrombolysis
  • Crohn's disease
  • Gastrointestinal haemorrhage
  • Inflammatory bowel disease
  • Thromboembolism

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Catheter-directed thrombolysis in inflammatory bowel diseases : Report of a case. / Ilonczai, Péter; Tóth, Judit; Tóth, L.; Altorjay, I.; Boda, Z.; Palatka, K.

In: World Journal of Gastroenterology, Vol. 18, No. 34, 2012, p. 4791-4793.

Research output: Contribution to journalArticle

@article{dd6cb4b41bb44b3cb1c26940781041e7,
title = "Catheter-directed thrombolysis in inflammatory bowel diseases: Report of a case",
abstract = "the prevalence of thrombosis is 6.2{\%}, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. The TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. The application of anticoagulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. The control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. This case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.",
keywords = "Catheter-directed thrombolysis, Crohn's disease, Gastrointestinal haemorrhage, Inflammatory bowel disease, Thromboembolism",
author = "P{\'e}ter Ilonczai and Judit T{\'o}th and L. T{\'o}th and I. Altorjay and Z. Boda and K. Palatka",
year = "2012",
doi = "10.3748/wjg.v18.i34.4791",
language = "English",
volume = "18",
pages = "4791--4793",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "34",

}

TY - JOUR

T1 - Catheter-directed thrombolysis in inflammatory bowel diseases

T2 - Report of a case

AU - Ilonczai, Péter

AU - Tóth, Judit

AU - Tóth, L.

AU - Altorjay, I.

AU - Boda, Z.

AU - Palatka, K.

PY - 2012

Y1 - 2012

N2 - the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. The TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. The application of anticoagulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. The control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. This case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.

AB - the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (TE) is 3.6 times higher compared to normal population. The TE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. The application of anticoagulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDT). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDT with recombinant tissue plasminogen activator was performed. The control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. This case supports that CDT-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening TE and active IBD.

KW - Catheter-directed thrombolysis

KW - Crohn's disease

KW - Gastrointestinal haemorrhage

KW - Inflammatory bowel disease

KW - Thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=84867735732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867735732&partnerID=8YFLogxK

U2 - 10.3748/wjg.v18.i34.4791

DO - 10.3748/wjg.v18.i34.4791

M3 - Article

C2 - 23002351

AN - SCOPUS:84867735732

VL - 18

SP - 4791

EP - 4793

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 34

ER -