Cathepsin d activity in otosclerotic bone and perilymph

Ottó Ribári, István Sziklai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Otosclerotic bone and perilymph samples obtained during stapedectomy operations from patients suffering from pure conductive hearing loss of at least 40 dBs air-bone gap at 500 Hz. Control perilymph samples derived from patients suffering from round window membrane rupture or Meniere's disease. Enzyme activities were determined using a synthetic fluorogenic substrate by fluorescence spectrophotometry. No significant differences have been found between the protein content of otosclerotic and normal or non-otosclerotic perilymph samples. Cathepsin D activity was significantly higher (p<0.001) in the otosclerotic perilymph samples. Otosclerotic stapes footplate contained more activity than normal meatal cortical bone as well, though the difference was not significant. Biological significance of the elevated Cathepsin D activity must be considered.

Original languageEnglish
Pages (from-to)549-552
Number of pages4
JournalActa Oto-Laryngologica
Volume105
Issue number5-6
DOIs
Publication statusPublished - Jan 1 1988

Keywords

  • Cathepsin D
  • Glucosaminoglycans
  • Otosclerosis
  • Perilymph

ASJC Scopus subject areas

  • Otorhinolaryngology

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