Catecholamine utilization in specific rat brain nuclei after short-term hyperprolactinaemia

G. Kovács, Filippo Drago, László Acsai, Ágnes Tihanyi, Umberto Scapagnini, G. Telegdy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Endogenous hyperprolactinaemia was induced in intact male rats by transplantation of pituitaries under the kidney capsule. Five days later the utilization of noradrenaline (NA) and dopamine (DA) in individual brain nuclei and changes of plasma prolaction (PRL) were measured. Inhibition of catecholamine synthesis by α-methyl-ptyrosine (α-MPT) was used to measure utilization. Hyperprolactinaemia increased the utilization of NA in the locus coeruleus, the cell-body region of the dorsal noradrenergic bundle (DNB), but decreased it in some terminal projections of the same pathway (e.g. the cingulate gyrus). DA utilization was increased by hyperprolactinaemia in the eminentia mediana. In the nigrostriatal DA-ergic projection, hyperprolactinaemia decreased the utilization of DA in the cell-body region (substantia nigra) and increased it in the terminal projection (nucleus caudatus). In the ventral tegmental area (mesolimbic DA-ergic projection), hyperprolactinaemia decreased the utilization of DA. It is concluded that hyperprolactinaemia affects neurotransmission in the hypothalamus and also in specific extrahypothalamic pathways (e.g. DNB, nigrostriatal and mesolimbic DA-ergic projections) and that these changes may correlate with some behavioural effects of the pituitary hormone.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalBrain Research
Volume324
Issue number1
DOIs
Publication statusPublished - Dec 17 1984

Fingerprint

Hyperprolactinemia
Catecholamines
Dopamine
Brain
Body Regions
Norepinephrine
Median Eminence
Ventral Tegmental Area
Locus Coeruleus
Pituitary Hormones
Caudate Nucleus
Gyrus Cinguli
Substantia Nigra
Synaptic Transmission
Hypothalamus
Capsules
Transplantation
Kidney

Keywords

  • brain nuclei
  • hyperprolactinaemia
  • NA and DA utilization
  • pituitary homograft

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Catecholamine utilization in specific rat brain nuclei after short-term hyperprolactinaemia. / Kovács, G.; Drago, Filippo; Acsai, László; Tihanyi, Ágnes; Scapagnini, Umberto; Telegdy, G.

In: Brain Research, Vol. 324, No. 1, 17.12.1984, p. 29-34.

Research output: Contribution to journalArticle

Kovács, G. ; Drago, Filippo ; Acsai, László ; Tihanyi, Ágnes ; Scapagnini, Umberto ; Telegdy, G. / Catecholamine utilization in specific rat brain nuclei after short-term hyperprolactinaemia. In: Brain Research. 1984 ; Vol. 324, No. 1. pp. 29-34.
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