Catecholamine levels in peripheral blood lymphocytes from multiple sclerosis patients

Cecilia Rajda, K. Bencsik, László Vécsei L, Jonas Bergquist

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Circumstantial evidence suggests the involvement of sympathoadrenergic mechanisms in the progress of multiple sclerosis (MS). We studied peripheral blood lymphocytes from MS patients. The levels of dopamine (DA), norepinephrine (NE), epinephrine (E) and their metabolites in extracts of lymphocytes from 58 MS patients and 19 healthy controls were measured by using capillary electrophoresis. The MS patients were divided into clinical subgroups: a laboratory-supported definitive (first-attack) MS group, and a relapsing-remitting (RR) group in remission. The peripheral blood lymphocyte level of epinephrine was significantly higher in the first-attack MS patients (p=0.028) than in the controls. However, the norepinephrine levels were significantly (p=0.027) lower in the RR patients in remission. The catecholamines are known to be able to affect the lymphocyte activity, both by stimulation and by immunosuppression. Our results suggest that the catecholamines are important regulators of lymphocyte activation in MS, and of potential importance as concerns new diagnostic and therapeutic methods.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalJournal of Neuroimmunology
Volume124
Issue number1-2
DOIs
Publication statusPublished - 2002

Fingerprint

Multiple Sclerosis
Catecholamines
Lymphocytes
Epinephrine
Norepinephrine
Capillary Electrophoresis
Lymphocyte Activation
Immunosuppression
Dopamine

Keywords

  • Capillary electrophoresis
  • Catecholamine
  • Dopamine
  • Epinephrine
  • Lymphocytes
  • Multiple sclerosis
  • Norepinephrine
  • Peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Catecholamine levels in peripheral blood lymphocytes from multiple sclerosis patients. / Rajda, Cecilia; Bencsik, K.; Vécsei L, László; Bergquist, Jonas.

In: Journal of Neuroimmunology, Vol. 124, No. 1-2, 2002, p. 93-100.

Research output: Contribution to journalArticle

Rajda, Cecilia ; Bencsik, K. ; Vécsei L, László ; Bergquist, Jonas. / Catecholamine levels in peripheral blood lymphocytes from multiple sclerosis patients. In: Journal of Neuroimmunology. 2002 ; Vol. 124, No. 1-2. pp. 93-100.
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