Catechol estrogens as inhibitors of leukotriene synthesis

Juha Alanko, Eeva Sievi, Tuula Lähteenmäki, I. Muchá, Heikki Vapaatalo, Jouko Parantainen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Estrogens have a beneficial effect on atherosclerosis and osteoporosis after menopause, but their exact mechanism of action is still unknown. The aim of the present study was to investigate the effects of estradiol and its metabolites catechol estrogens on arachidonic acid metabolism in vitro. Estradiol had no effect on arachidonic acid metabolism up to 33 μM in A23187-stimulated human whole blood. All catechol estrogens (2-hydroxyestradiol, 2-hydroxyestrone, 4-hydroxyestradiol and 4-hydroxyestrone) had similar kinds of actions on arachidonic acid metabolism, being over ten times more potent inhibitors of leukotriene synthesis (IC50 values 0.044-0.16 μM) than thromboxane (IC50 values 0.99-2.1 μM) and prostaglandin E2 synthesis (IC50 values 0.84-5.5 μM). It is suggested that some of the protective actions of estrogens - e.g., on atherosclerosis and osteoporosis - may be related to the inhibition of leukotriene synthesis by catechol estrogens.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalBiochemical Pharmacology
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 1 1998

Fingerprint

Catechol Estrogens
Leukotrienes
Arachidonic Acid
Metabolism
Inhibitory Concentration 50
Osteoporosis
Estradiol
Atherosclerosis
Estrogens
Thromboxanes
Calcimycin
Menopause
Metabolites
Dinoprostone
Blood

Keywords

  • Estradiol
  • Estrogen
  • Leukotriene
  • Prostaglandin
  • Thromboxane

ASJC Scopus subject areas

  • Pharmacology

Cite this

Alanko, J., Sievi, E., Lähteenmäki, T., Muchá, I., Vapaatalo, H., & Parantainen, J. (1998). Catechol estrogens as inhibitors of leukotriene synthesis. Biochemical Pharmacology, 55(1), 101-104. https://doi.org/10.1016/S0006-2952(97)00398-5

Catechol estrogens as inhibitors of leukotriene synthesis. / Alanko, Juha; Sievi, Eeva; Lähteenmäki, Tuula; Muchá, I.; Vapaatalo, Heikki; Parantainen, Jouko.

In: Biochemical Pharmacology, Vol. 55, No. 1, 01.01.1998, p. 101-104.

Research output: Contribution to journalArticle

Alanko, J, Sievi, E, Lähteenmäki, T, Muchá, I, Vapaatalo, H & Parantainen, J 1998, 'Catechol estrogens as inhibitors of leukotriene synthesis', Biochemical Pharmacology, vol. 55, no. 1, pp. 101-104. https://doi.org/10.1016/S0006-2952(97)00398-5
Alanko J, Sievi E, Lähteenmäki T, Muchá I, Vapaatalo H, Parantainen J. Catechol estrogens as inhibitors of leukotriene synthesis. Biochemical Pharmacology. 1998 Jan 1;55(1):101-104. https://doi.org/10.1016/S0006-2952(97)00398-5
Alanko, Juha ; Sievi, Eeva ; Lähteenmäki, Tuula ; Muchá, I. ; Vapaatalo, Heikki ; Parantainen, Jouko. / Catechol estrogens as inhibitors of leukotriene synthesis. In: Biochemical Pharmacology. 1998 ; Vol. 55, No. 1. pp. 101-104.
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