Katatónia és neuroleptikus malignus szindróma a pszichopatológiai és patofiziológiai átfedések tükrében: Rövid összefoglaló tanulmány

Translated title of the contribution: Catatonia and neuroleptic malignant syndrome in view of a psychopathological and pathophysiological overlap: A brief review

Asztalos Zoltán, Egervári Luca, Andrássy Gábor, G. Faludi, Frecska Ede

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Catatonia was first described in the 19th century as a syndrome with motor, affective and behavioral symptoms. During the 20th century it was rather regarded as a rare motoric manifestation of schizophrenia and that classification has almost resulted in the disappearance of catatonia among patients outside of the schizophrenia spectrum. With the introduction of neuroleptics, the incidence of catatonic schizophrenia also declined which was attributed to effective treatment. Simultaneously, neuroleptic malignant syndrome was described, which shows many similarities with catatonia. Recently, several researchers suggested a common origin of the two disorders. In this paper we review case reports of the last five years, in which both neuroleptic malignant syndrome and catatonia had emerged as a diagnosis. Additionally, based on the relevant literature, we propose a common hypothetical pathomechanism with therapeutic implications for the two syndromes. Besides underlining the difficulties of differential diagnosis, the reviewed cases demonstrate a transition between the two illnesses. The similarities and the possible shifts may suggest a neuropathological and pathophysiological overlap in the background of the two syndromes. Electroconvulsive therapy and benzodiazepines seem to be an effective treatment in both syndromes. These two treatment approaches can be highly valuable in clinical practice, especially if one considers the difficulties of differential diagnosis.

Original languageHungarian
Pages (from-to)19-28
Number of pages10
JournalNeuropsychopharmacologia Hungarica
Volume16
Issue number1
Publication statusPublished - 2014

Fingerprint

Catatonia
Neuroleptic Malignant Syndrome
Schizophrenia
Catatonic Schizophrenia
Differential Diagnosis
Behavioral Symptoms
Affective Symptoms
Electroconvulsive Therapy
Therapeutics
Benzodiazepines
Antipsychotic Agents
Research Personnel
Incidence

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Katatónia és neuroleptikus malignus szindróma a pszichopatológiai és patofiziológiai átfedések tükrében : Rövid összefoglaló tanulmány. / Zoltán, Asztalos; Luca, Egervári; Gábor, Andrássy; Faludi, G.; Ede, Frecska.

In: Neuropsychopharmacologia Hungarica, Vol. 16, No. 1, 2014, p. 19-28.

Research output: Contribution to journalArticle

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