A GYERMEKKORI KATASZTROFALIS EPILEPSZIAK ES MUTETI KEZELESUK

Translated title of the contribution: Catastrophic childhood epilepsy and its surgical treatment

M. Neuwirth, J. Vajda

Research output: Contribution to journalArticle

Abstract

About 20% of epileptic children are intractable a part of them having catastrophic childhood epilepsies: West, Lennox-Gastaut's syndrome, Landau-Kleffner's syndrome with aphasia, Rasmussen encephalitis, brain malformations, phacomatosis, brain damage with epilepsy. Surgical treatment of-epilepsy, having shown fast development especially in the past decade, is a great hope of recovery for infants and young children with severe, intractable seizures. The presurgical evaluation of candidates consists;of a detailed history, neurological and neuropsychological examinations, anatomic and functional neuroimaging, the recording of ictal events by using simultaneous EEG and videomonitoring. Possibilities of the surgical treatment in catastrophic epilepsy are as follows: resection performed in partial epilepsy; hemispherotomy performed in hemimegalencephaly, Sturge-Weber's and Rasmussen's syndrome; corpus callosotomy performed in Lennox-Gastaut's syndrome, and brain malformation with generalized tonic seizure. Seven of our 15 patients (aged 3-18 years) have become seizure free since-the surgical treatment, six patients have shown only mild, rare seizures. All of them have been more active and attentive. Our conclusion is, that early onset seizure presentation may be associated with catastrophic outcomes, developmental arrest or regression, while the childhood nervous system typically exhibits superior functional recovery and therefore early surgery in children with intractable epilepsy is recommended.

Original languageHungarian
Pages (from-to)684-691
Number of pages8
JournalLege Artis Medicinae
Volume7
Issue number11
Publication statusPublished - 1997

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Epilepsy
Seizures
Encephalitis
Hope
Brain
Landau-Kleffner Syndrome
Therapeutics
Sturge-Weber Syndrome
Neurocutaneous Syndromes
Functional Neuroimaging
Partial Epilepsy
Aphasia
Neurologic Examination
Nervous System
Electroencephalography
History
Stroke
Lennox Gastaut Syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A GYERMEKKORI KATASZTROFALIS EPILEPSZIAK ES MUTETI KEZELESUK. / Neuwirth, M.; Vajda, J.

In: Lege Artis Medicinae, Vol. 7, No. 11, 1997, p. 684-691.

Research output: Contribution to journalArticle

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