Catalytic hydrogenation and deuteration of phospholipid model membranes with a water-soluble chlorotris(1,3,5-triaza-7-phosphaadamantane)rhodium(I) complex catalyst

L. Nadasdi, Ferenc Joó

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The water-soluble chlorotris(1,3,5-triaza-7-phosphaadamantane)rhodium(I), [RhCl(PTA)3], was successfully employed for hydrogenation of phospholipid liposomes as model membranes in aqueous media under mild conditions. The highest conversion was achieved at pH 4.70. Formation of asymmetrically dideuterated lipids, together with isomerization and kinetic results revealed the important role of reversible formation of an alkyl-rhodium intermediate in the mechanism.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalInorganica Chimica Acta
Volume293
Issue number2
Publication statusPublished - Oct 15 1999

Fingerprint

Rhodium
Hydrogenation
Phospholipids
rhodium
hydrogenation
membranes
Membranes
catalysts
Catalysts
Water
Liposomes
Isomerization
Lipids
water
isomerization
lipids
Kinetics
kinetics
1,3,5-triaza-7-phosphaadamantane

Keywords

  • Catalytic hydrogenation
  • Phosphaadamantane complexes
  • Phospholipids
  • Rhodium complexes

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

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T1 - Catalytic hydrogenation and deuteration of phospholipid model membranes with a water-soluble chlorotris(1,3,5-triaza-7-phosphaadamantane)rhodium(I) complex catalyst

AU - Nadasdi, L.

AU - Joó, Ferenc

PY - 1999/10/15

Y1 - 1999/10/15

N2 - The water-soluble chlorotris(1,3,5-triaza-7-phosphaadamantane)rhodium(I), [RhCl(PTA)3], was successfully employed for hydrogenation of phospholipid liposomes as model membranes in aqueous media under mild conditions. The highest conversion was achieved at pH 4.70. Formation of asymmetrically dideuterated lipids, together with isomerization and kinetic results revealed the important role of reversible formation of an alkyl-rhodium intermediate in the mechanism.

AB - The water-soluble chlorotris(1,3,5-triaza-7-phosphaadamantane)rhodium(I), [RhCl(PTA)3], was successfully employed for hydrogenation of phospholipid liposomes as model membranes in aqueous media under mild conditions. The highest conversion was achieved at pH 4.70. Formation of asymmetrically dideuterated lipids, together with isomerization and kinetic results revealed the important role of reversible formation of an alkyl-rhodium intermediate in the mechanism.

KW - Catalytic hydrogenation

KW - Phosphaadamantane complexes

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KW - Rhodium complexes

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VL - 293

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JO - Inorganica Chimica Acta

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