Catalyst-free P-C coupling reactions of halobenzoic acids and secondary phosphine oxides under microwave irradiation in water

Erzsébet Jablonkai, György Keglevich

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4-Bromo and 3-bromobenzoic acids along with 4-iodobenzoic acid underwent P-C coupling reactions with diarylphosphine oxides in the absence of any catalyst in water as the solvent under microwave irradiation. The phosphinoylbenzoic acids obtained were converted into the corresponding ethyl esters in yields of 59-82%.

Original languageEnglish
Pages (from-to)1638-1640
Number of pages3
JournalTetrahedron Letters
Issue number13
Publication statusPublished - Mar 25 2015



  • Catalyst-free
  • Hirao reaction
  • Microwave-assisted
  • P-C coupling
  • Secondary phosphine oxide
  • Triarylphosphine oxide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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