Catalyst-free P-C coupling reactions of halobenzoic acids and secondary phosphine oxides under microwave irradiation in water

Erzsébet Jablonkai, G. Keglevich

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

4-Bromo and 3-bromobenzoic acids along with 4-iodobenzoic acid underwent P-C coupling reactions with diarylphosphine oxides in the absence of any catalyst in water as the solvent under microwave irradiation. The phosphinoylbenzoic acids obtained were converted into the corresponding ethyl esters in yields of 59-82%.

Original languageEnglish
Pages (from-to)1638-1640
Number of pages3
JournalTetrahedron Letters
Volume56
Issue number13
DOIs
Publication statusPublished - Mar 25 2015

Fingerprint

phosphine
Bromobenzoates
Iodobenzoates
Microwave irradiation
Microwaves
Oxides
Esters
Catalysts
Acids
Water

Keywords

  • Catalyst-free
  • Hirao reaction
  • Microwave-assisted
  • P-C coupling
  • Secondary phosphine oxide
  • Triarylphosphine oxide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Catalyst-free P-C coupling reactions of halobenzoic acids and secondary phosphine oxides under microwave irradiation in water. / Jablonkai, Erzsébet; Keglevich, G.

In: Tetrahedron Letters, Vol. 56, No. 13, 25.03.2015, p. 1638-1640.

Research output: Contribution to journalArticle

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