Cataleptogenic and anticataleptic activity produced by cholecystokinin octapeptides in mice

Tibor Kádár, Lóránt Borda, B. Penke, Kálmán Kovács, G. Telegdy

Research output: Contribution to journalArticle

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Abstract

The catalepsy induced by subcutaneously (sc.) and intracerebroventricularly (icv.) administered cholecystokinin octapeptide sulfate ester (CCK-8-SE) and desulfated cholecystokinin octapeptide (CCK-8-NS), and the effects of CCK-8-SE and CCK-8-NS on haloperidol-induced catalepsy, were investigated in mice. The results demonstrate the bimodal effect of CCK octapeptides in a catalepsy test. With sc. administration CCK-8-SE in the doses of 0.4 or 0.8 μmole/kg, but not CCK-8-NS at any dose, induced catalepsy. Furthermore, the catalepsy induced by CCK-8-SE was of short duration. With icv. administration only 40 pmole CCK-8-NS induced significant catalepsy. When 0.2, 0.4 and 0.8 μmole/kg sc. doses of CCK-8-NS or 0.4 pmole icv. dose of CCK-8-SE or CCK-8-NS was given in combination with intraperitoneal (ip.) administration of 1.0 mg/kg haloperidol, the total duration of catalepsy was suppressed. Finally, CCK-8-SE sc. when given in combination with haloperidol ip., exerted a biphasic, synergistic-antagonistic effect on the haloperidol-induced catalepsy.

Original languageEnglish
Pages (from-to)259-268
Number of pages10
JournalNeuropeptides
Volume6
Issue number3
DOIs
Publication statusPublished - 1985

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Sincalide
Catalepsy
Haloperidol
Sulfates

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Cataleptogenic and anticataleptic activity produced by cholecystokinin octapeptides in mice. / Kádár, Tibor; Borda, Lóránt; Penke, B.; Kovács, Kálmán; Telegdy, G.

In: Neuropeptides, Vol. 6, No. 3, 1985, p. 259-268.

Research output: Contribution to journalArticle

Kádár, Tibor ; Borda, Lóránt ; Penke, B. ; Kovács, Kálmán ; Telegdy, G. / Cataleptogenic and anticataleptic activity produced by cholecystokinin octapeptides in mice. In: Neuropeptides. 1985 ; Vol. 6, No. 3. pp. 259-268.
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