Catalepsy, hypermotility, increase of striatal acetylcholine release induced by morphine and Met-enkephalin as affected by prolonged hydrocortisone and ACTH treatment

B. Kanyicska, A. Simonyi, L. Hársing

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the rats treated with ACTH or hydrocortisone for 14 days the catalepsy induced by morphine was almost completely inhibited, while the haloperidol induced catalepsy remained unchanged. The morphine induced hypermotility was altered neither by prolonged treatment with ACTH nor by an acute glucocorticoid administration. Inhibition of Na/K ATPase by ouabain led to an increase of striatal acetylcholine (Ach) release, which was enhanced by Met-enkephalin. This effect of the opioid peptide was not demonstrable in the striata of ACTH or hydrocortisone pretreated rats. It is concluded that glucocorticoids are regulatory factors of the striatal opiate neurotransmission possibly via altered receptorial mechanisms.

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalPolish Journal of Pharmacology and Pharmacy
Volume37
Issue number3
Publication statusPublished - 1985

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Catalepsy
Corpus Striatum
Methionine Enkephalin
Adrenocorticotropic Hormone
Morphine
Acetylcholine
Hydrocortisone
Glucocorticoids
Opiate Alkaloids
Opioid Peptides
Haloperidol
Ouabain
Synaptic Transmission

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

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