Catalase deficiency may complicate urate oxidase (rasburicase) therapy

László Góth, N. William Bigler

Research output: Contribution to journalComment/debate

16 Citations (Scopus)

Abstract

Patients with low (inherited and acquired) catalase activities who are treated with infusion of uric acid oxidase because they are at risk of tumour lysis syndrome may experience very high concentrations of hydrogen peroxide. They may suffer from methemoglobinaemia and haemolytic anaemia which may be attributed either to deficiency of glucose-6-phosphate dehydrogenase or to other unknown circumstances. Data have not been reported from catalase deficient patients who were treated with uric acid oxidase. It may be hypothesized that their decreased blood catalase could lead to the increased concentration of hydrogen peroxide which may cause haemolysis and formation of methemoglobin. Blood catalase activity should be measured for patients at risk of tumour lysis syndrome prior to uric acid oxidase treatment.

Original languageEnglish
Pages (from-to)953-955
Number of pages3
JournalFree radical research
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 6 2007

Keywords

  • Blood catalase
  • Catalase deficiency
  • Haemolysis
  • Tumour lysis syndrome
  • Urate acid oxidase treatment

ASJC Scopus subject areas

  • Biochemistry

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