Ca2+/calcineurin-lnhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory

F. A. Antoni, M. Palkóvits, J. Simpson, S. M. Smith, A. L. Leitch, R. Rosie, G. Fink, J. M. Paterson

Research output: Contribution to journalArticle

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Abstract

Activation of cAMP synthesis by intracellular Ca2+ is thought to be the main mode of cAMP generation in the brain. Accordingly, the Ca2+- activated adenylyl cyclases I and VIII are expressed prominently in forebrain neurons. The present study shows that the novel adenylyl cyclase type IX is inhibited by Ca2+ and that this effect is blocked selectively by inhibitors of calcineurin such as FK506 and cyclosporin A. Moreover, adenylyl cyclase IX is inhibited by the same range of intracellular free Ca2+ concentrations that stimulate adenlyl cyclase I. Adenylyl cyclase IX is expressed prominently in the forebrain. Substantial arrays of neurons positive for AC9 mRNA were found in the olfactory lobe, in limbic and neocortical areas, in the striatum, and in the cerebellar system. These data show that the initiation of the cAMP signal by adenylyl cyclase may be controlled by Ca2+/calcineurin and thus provide evidence for a novel mode of tuning the cAMP signal by protein phosphorylation-/dephosphorylation cascades.

Original languageEnglish
Pages (from-to)9650-9661
Number of pages12
JournalJournal of Neuroscience
Volume18
Issue number23
Publication statusPublished - Dec 1 1998

Fingerprint

Calcineurin
Prosencephalon
Adenylyl Cyclases
Learning
Neurons
Tacrolimus
Cyclosporine
Phosphorylation
Messenger RNA
Brain
adenylate cyclase 9
Proteins

Keywords

  • Adenylyl cyclase I
  • Calcium
  • cAMP
  • Hippocampus
  • Neocortex
  • Protein phosphatase
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Antoni, F. A., Palkóvits, M., Simpson, J., Smith, S. M., Leitch, A. L., Rosie, R., ... Paterson, J. M. (1998). Ca2+/calcineurin-lnhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. Journal of Neuroscience, 18(23), 9650-9661.

Ca2+/calcineurin-lnhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. / Antoni, F. A.; Palkóvits, M.; Simpson, J.; Smith, S. M.; Leitch, A. L.; Rosie, R.; Fink, G.; Paterson, J. M.

In: Journal of Neuroscience, Vol. 18, No. 23, 01.12.1998, p. 9650-9661.

Research output: Contribution to journalArticle

Antoni, FA, Palkóvits, M, Simpson, J, Smith, SM, Leitch, AL, Rosie, R, Fink, G & Paterson, JM 1998, 'Ca2+/calcineurin-lnhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory', Journal of Neuroscience, vol. 18, no. 23, pp. 9650-9661.
Antoni, F. A. ; Palkóvits, M. ; Simpson, J. ; Smith, S. M. ; Leitch, A. L. ; Rosie, R. ; Fink, G. ; Paterson, J. M. / Ca2+/calcineurin-lnhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 23. pp. 9650-9661.
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