Case study

Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results

Milena Černá, Marek Malý, P. Rudnai, Szilvia Középesy, Miklós Náray, Katarina Halzlová, Michal Jajcaj, Anna Grafnetterová, Andrea Krsková, Danuše Antošová, Kateřina Forysová, Elly Den Hond, Greet Schoeters, Reinhard Joas, Ludwine Casteleyn, Anke Joas, Pierre Biot, Dominique Aerts, Jürgen Angerer, Louis Bloemen & 7 others Argelia Castaño, Marta Esteban, Holger M. Koch, Marike Kolossa-Gehring, Arno C. Gutleb, Jana Pavloušková, Karel Vrbík

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: Phthalates and their metabolites are classified as endocrine modulators. They affect the hormonal balance in both children and adults.The aim of this publication was to compare the urinary levels of phthalate metabolites in selected populations of the Czech Republic (CZ), Slovakia (SK), and Hungary (HU) in relation to the sources of phthalate exposure identified by means of questionnaire (personal care products, floor and wall coverings, plastic toys, and some kinds of foods). Methods: Data were obtained through the twin projects COPHES (COnsortium to Perform Human biomonitoring on a European Scale) and DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) from 2009 to 2012. The target groups were children aged 6-11 years old and their mothers up to 45 years of age. The metabolites of phthalates (monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobenzyl phthalate (MBzP), mono-cyclohexyl phthalate (MCHP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), and mono-(2-ethyl-5-oxohexyl) phthalate (5OXO-MEHP)) were analysed in first morning urine samples. After enzymatic glucuronide cleavage, the urine sample analyses were performed using ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) in one laboratory that qualified in the External Quality Assessment exercises organised by COPHES. Results: Significant differences in phthalate exposure between countries were revealed for children only but not for mothers. The concentrations of 5-OH-MEHP (P

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalEnvironmental Research
Volume141
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

phthalate
Metabolites
Population
Environmental Monitoring
Roof coverings
Electrospray ionization
Glucuronides
High performance liquid chromatography
Mothers
Urine
Modulators
Slovakia
Play and Playthings
Mass spectrometry
metabolite
Electrospray Ionization Mass Spectrometry
Hungary
Czech Republic
Demonstrations
Tandem Mass Spectrometry

Keywords

  • Czech Republic
  • DEMOCOPHES
  • Hungary
  • Slovakia
  • Urinary phthalate metabolites

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry

Cite this

Case study : Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results. / Černá, Milena; Malý, Marek; Rudnai, P.; Középesy, Szilvia; Náray, Miklós; Halzlová, Katarina; Jajcaj, Michal; Grafnetterová, Anna; Krsková, Andrea; Antošová, Danuše; Forysová, Kateřina; Hond, Elly Den; Schoeters, Greet; Joas, Reinhard; Casteleyn, Ludwine; Joas, Anke; Biot, Pierre; Aerts, Dominique; Angerer, Jürgen; Bloemen, Louis; Castaño, Argelia; Esteban, Marta; Koch, Holger M.; Kolossa-Gehring, Marike; Gutleb, Arno C.; Pavloušková, Jana; Vrbík, Karel.

In: Environmental Research, Vol. 141, 01.08.2015, p. 118-124.

Research output: Contribution to journalArticle

Černá, M, Malý, M, Rudnai, P, Középesy, S, Náray, M, Halzlová, K, Jajcaj, M, Grafnetterová, A, Krsková, A, Antošová, D, Forysová, K, Hond, ED, Schoeters, G, Joas, R, Casteleyn, L, Joas, A, Biot, P, Aerts, D, Angerer, J, Bloemen, L, Castaño, A, Esteban, M, Koch, HM, Kolossa-Gehring, M, Gutleb, AC, Pavloušková, J & Vrbík, K 2015, 'Case study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results', Environmental Research, vol. 141, pp. 118-124. https://doi.org/10.1016/j.envres.2014.10.025
Černá, Milena ; Malý, Marek ; Rudnai, P. ; Középesy, Szilvia ; Náray, Miklós ; Halzlová, Katarina ; Jajcaj, Michal ; Grafnetterová, Anna ; Krsková, Andrea ; Antošová, Danuše ; Forysová, Kateřina ; Hond, Elly Den ; Schoeters, Greet ; Joas, Reinhard ; Casteleyn, Ludwine ; Joas, Anke ; Biot, Pierre ; Aerts, Dominique ; Angerer, Jürgen ; Bloemen, Louis ; Castaño, Argelia ; Esteban, Marta ; Koch, Holger M. ; Kolossa-Gehring, Marike ; Gutleb, Arno C. ; Pavloušková, Jana ; Vrbík, Karel. / Case study : Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results. In: Environmental Research. 2015 ; Vol. 141. pp. 118-124.
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AU - Malý, Marek

AU - Rudnai, P.

AU - Középesy, Szilvia

AU - Náray, Miklós

AU - Halzlová, Katarina

AU - Jajcaj, Michal

AU - Grafnetterová, Anna

AU - Krsková, Andrea

AU - Antošová, Danuše

AU - Forysová, Kateřina

AU - Hond, Elly Den

AU - Schoeters, Greet

AU - Joas, Reinhard

AU - Casteleyn, Ludwine

AU - Joas, Anke

AU - Biot, Pierre

AU - Aerts, Dominique

AU - Angerer, Jürgen

AU - Bloemen, Louis

AU - Castaño, Argelia

AU - Esteban, Marta

AU - Koch, Holger M.

AU - Kolossa-Gehring, Marike

AU - Gutleb, Arno C.

AU - Pavloušková, Jana

AU - Vrbík, Karel

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