Male F-344 rats were treated with CCI4 (0.2 mL/kg three times a week) and phenobarbital (0.2 g/L in drinking water) for 12 weeks. A group of animals received an additional treatment with kappacarrageenan (5 mg/animal intraperitoneally on days 21,49, and 77 of the experiment), liver cirrhosis developed after both kinds of treatment by the end of the 12th week. Six weeks after the termination of the treatment the amount of liver collagen (measured by morphometry and by dye elution) decreased significantly in the CCI4 and phenobarbital-treated group, but not in the animals that also received carrageenan. An important role for macrophages in the degradation and resorption of collagen is emphasized. Carrageenan supplementation of CCl4 and phenobarbital treatment may provide a good experimental model of non-regressing liver cirrhosis. Caution is advised regarding carrageenan intake for humans with any preexisting liver damage.
|Number of pages||11|
|Journal||journal of environmental science and health. part a: environmental science and engineering and toxicology|
|Publication status||Published - Feb 1 1992|
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